Chapter 9 PPT Flashcards
What are the three types of muscle tissue in the muscular system?
Skeletal
Cardiac
Smooth
Skeletal muscle attached to
bones of skeleton
skeletal muscle - control type?
voluntary
cardiac muscle makes up most of the
wall of the heart
cardiac muscle control type?
involuntary (non-consciously controlled)
cardiac muscle responsible for
pumping action of the heart
smooth muscle found in
walls of internal organs, such as those of digestive tract
smooth muscle control type
involuntary
skeletal muscle composed of
skeletal muscle tissue
nervous tissue
blood
connective tissue
connective tissue covering over skeletal muscles
fascia
tendons
aponeuroses
muscle coverings examples
epimysium
perimysium
endomysium
what is the epimysium?
surrounds whole muscle
what is the perimysium?
surrounds fascicles within a muscle
what is the endomysium?
surrounds muscle fibers within a fasicle
skeletal muscle fibers have what type of nucleus?
multinucleated
skeletal muscle have many
myofibrils
skeletal muscle - what do myofibrils consist of?
thin actin filaments
thick myosin filaments
sacromeres that are connected end-to-end
skeletal muscle - striation pattern is made by
arrangement of myofilaments in myofibrils
What structures do sarcomeres contain?
I Band A Band H Zone Z Line M Line
what is in the I band?
thin filaments
what is in the A band
thick and thin filaments
what is in the H zone
thick filaments
what is the z line also known as?
Z disc
Striation pattern has what 2 main parts?
I Band and A Band
What is the I Band?
Light band, composed of thin actin filaments
what is the a band?
dark band, composed of thick myosin filaments with portions overlapped with thin actin filaments
What is the H zone?
Center of A band; composed of thick myosin filaments
What is the Z Line?
Anchors filaments in place; sarcomere boundary; center of I band
What is the M line?
Anchors thick filaments; center of A band
thick filaments are composed of
myosin proteins; heads form cross-bridges
thin filaments are composed of
actin protein; associated with troponin and tropomyosin, which prevent cross-bridge formation when muscle is not contracting
Contraction of a muscle fiber requires
interaction from several chemical and cellular components
Contraction of a muscle fiber results from
a movement within the myofibrils, in which the actin and myosin filaments slide past one another, shortening the sarcomeres
Contraction of a muscle fiber - muscle fiber shortens and
pulls on attachment point
a neuromuscular junction is a type of
synpase
a neuromuscular junction is also called a
myoneural junction
a neuromuscular junction site where
an axon of motor neuron and skeletal muscle fiber interact
a neuromuscular junction - skeletal fibers contract only when stimulated by a
motor neuron
parts of the NMJ?
Motor Neuron Motor End Plate Synaptic Cleft Synaptic Vesicles Neurotransmitters
What is the neurotransmitter for contraction?
Acetylcholine (ACh)
Stimulus for contraction - nerve impulse causes release of
ACh from synaptic vesicles
Stimulus for contraction - Ach binds to
ACh receptors on motor end plate
Stimulus for contraction - ACh causes change in
membrane permeability to Na+ and K+ which generates a muscle impulse (action potential)
Stimulus for contraction - impulse causes
release of Ca2+ from SR, which leads to muscle contraction
What is MG?
Myoasthenia Gravis, an autoimmune disorder
What happens in Myoasthenia Gravis?
Antibodies attach ACh receptors on skeletal muscle fibers (motor end plates) in neuromuscular junctions)
In MG, person may only have
one-third normal number of ACh receptors
MG leads to widespread
muscle weakness and muscle fatigue
Treatments for MG?
Drugs that inhibit ACh
Immunosuppresant Drugs
Administering antibodies that inactivate harmful antibodies
Plasma exchange
What is excitation-contraction coupling
connection between muscle fiber stimulation and muscle contraction
what occurs during muscle relaxation?
Ca2+ ions are stored in SR
Troponin-Tropomyosin complexes cover binding sites on actin filaments
Upon muscle stimulation - muscle impulses cause
SRS to release Ca2+ ions into cytosol
Upon muscle stimulation - Ca2+ on binds to
troponin to change its shape
Upon muscle stimulation - each tropomyosin is
held in place by a troponin molecule. The change in shape of troponin alters the position of tropomyosin
Upon muscle stimulation - binding sites on actin are now
exposed
Upon muscle stimulation - myosin heads bind to
actin - forming cross-bridges
sliding filament model of muscle contraction - when sarcomeres shorten
thick and thin filaments slide past one another
sliding filament model of muscle contraction - H zone and I bands
narrow
sliding filament model of muscle contraction - z lines move
closer together
sliding filament model of muscle contraction - thick and thin filaments
do not change length
sliding filament model of muscle contraction - overlap between
filaments increases
cross-bridge cycling - (1) myosin head attaches to
actin binding site, forming cross-bridge
cross-bridge cycling - (2) myosin cross-bridge pulls
thin filament toward center of sacromere
cross-bridge cycling - (3) ADP and phosphate are
released from myosin
cross-bridge cycling - (4) new atp
binds to myosin
cross-bridge cycling - (5) linkage between actin and myosin
cross-bridge break
cross-bridge cycling - (6) atp
splits
cross-bridge cycling - (7) myosin cross-bridge goes back to
original position
When neural stimulation of muscle fiber stops - Acetylcholinesterase rapidly
decomposes ACh remaining in the synapse
When neural stimulation of muscle fiber stops - muscle impulse stops when
ACh is decomposed
When neural stimulation of muscle fiber stops - stimulus to sarcolemma and muscle fiber membrane
ceases
When neural stimulation of muscle fiber stops - calcium pump moves
Ca2+ back into sarcoplasmic reticulum (SR)
When neural stimulation of muscle fiber stops - troponin-tropomyosin complex again
covers binding sites on actin.
When neural stimulation of muscle fiber stops - myosin and actin binding sites are now
prevented
When neural stimulation of muscle fiber stops - at the end, muscle fiber
relaxes
Energy sources for contraction
ATP reserves : small amount
creatine phosphate: initial source of energy to regenerate ATP from ADP and P
Cellular respiration
What occurs in cellular respiration in anaerobic phase?
glycolysis
occurs in cytoplasm
produces little atp
what occurs in aerobic phase?
citric acid and ETC.
occurs in mitochondria
produces most of ATP
myoglobin stores extra oxygen in molecules
What is the Anaerobic (Lactic Acid) Threshold
Shift in metabolism from aerobic to anaerobic, during strenuous muscle activity, when the above systems cannot supply the necessary O2. Lactic acid is provided
what happens in oxygen debt?
amount of oxygen needed by liver cells convert the accumulated lactic acid to glucose and to restore muscle ATP and creatine phosphate concentrations
what occurs in muscle fatigue?
inability to contract muslces
common causes of muscle fatigue?
decreases blood flow
ion imbalances across the sarcolemma
loss of desire to continue exercise accumulation of lactic acid
what occurs in a muscle cramp?
sustained, involuntary muscle contraction
may be caused by changes in electrolyte concentration in extracellular fluids in the area
heat is a by-product of
cellular respiration in active cells
muscle cells are major source of
body heat
more than half the energy release in cellular respiration becomes
heat; less than half is transferred to ATP
blood transports ..
heat throughout body core
muscle contraction can be observed by
removing a single skeletal muscle fiber and connecting it to a device that senses and records skeletal changes int he overall length of the muscle fiber
what is the threshold stimulus?
minimum strength of stimulation of a muscle fiber required to cause contraction?
when strength of stimulus reaches threshold,
an action potential is generated
impuslse spreads through
muscle fiber, releasing Ca2+ from SR and activating crossbridge formation
one action potential from a motor neuron releases enough ACh to produce
threshold stimulus in muscle fiber, causing a muscle impulse
a twitch is
a contractile response of a single muscle fiber to a single impulse
what is in the twitch?
latent period
period of contration
period of relaxation
length of muscle fiber before sitmulation determines
amount of force it can develop
optimum starting length in length-tension relationship is
resting length of the muscle fiber; this allows the greatest force to develop
stretched muscle fibers develop less
force, since some myosin heads cannot reach binding sites of actin
shortened muscle fibers also develop
less force, since compressed
sacromeres cannot
shorten further
summation is a process by which
the force of individual muscle fiber twitches combine.
summation produces
sustained contractions
summation can lead to
partial or complete tetanic contractions
a motor unit consists of
a motor neuron plus all of the muscle fibers it controls
a whole muscle consists of many
motor units
corase movements are produced with
large numbers of fibers in a motor unit
precide movements are produced with
fewer muscle fibers in a motor unit
what is the recruitment of motor units?
Increase in the number of motor units activated, to produce more force
certain motor units are
activated first, and others are activated only when the intensity of stimulus increases
as intensity of stimulation increases,
recruitment of motor units continues until all motor units are activated
the smallest motor units (smaller diameter axons)
are recruited first
larger motor units (larger diameter axons) are
recruited later
summutation and recruitment can produce
sustained contractions of increasing strength
whole muscle contractions are
smooth movements
what is muscle tone?
continuous state of partial contraction in resting muscles.
what is isotonic?
muscle contracts and changes length in equal force
What is a concentric contraction?
muscle contracts with force greater than resistance and shorten
what is a eccentric contraction?
muscsle contracts with force less than resistance and length
what is isometric?
muscle contracts but does not change length
Type I fibers are
slow twitch fibers
type iia are
fast-twitch fatigue resistant fibers
type iib are
fast-twitch glycolytic fibers
type I fibers are always
oxidative
type I fibers are what to fatigue?
resistant to fatigue
type I fibers contain what type of fibers
red fibers
type I fibers feature an abundance of
myoglobin
type I fibers feature food
blood supply
type I fibers feature many
mitochondria
type I fibers have slow
atpase activity; slow to contract
type iib have what type of respiration
anaerobic respiration (glycolysis)
type iib have what type of fibers
white fibers (less myoglobin)
type iib have poor
blood supply
type iib mitochondria type
fewer mitochondria than fast-twitch
type iib - sr
more sr than fast twitch
type iib susceptible to
fatigue
type iib - atpase activity
fast atpase activity; contract rapidly
type iiA - twitch fiber type
intermediate twitch fibers
type iia - oxidative capacity
intermediate oxidative capacity
type iia - myoglobin
intermediate amount of myoglobin
type iia - fiber type
white fibers
type iia - fatigue
resistant to gatigue
type iia - atpase
rapid atpase activity
what is hypertrophy?
enlargement of skeletal muscle that is exercises
what is atrophy?
decrease in size and strength of skeletal muscle that is unused
aerobic exercise stimulates
slow-twitch fibers. In response, fibers increase their capillaries and mitochondria
forceful exercise stimulates mainly
fast twitch fibers. Inr esponse, fibers produce new actin and myosin filaments and the muscle enlarges
compared to skeletal muscle fibers, smooth muscle fibers are
shorter single nucleus elongated with tapering ends myofilaments randomly organized lack striations lack transverse tubules sr not well developed
what are the two types of smooth muscle?
multi-unit smooth muscle
visceral smooth msucle
in multi-unit smooth muscle, cells are
less organized
in multi-unit smooth muscle, function as
separate units
in multi-unit smooth muscle, fibers function
independtely
in multi-unit smooth muscle, found in
iris of eye, walls of blood vessels
in multi-unit smooth muscle, stimulated by
neurons, hormones
in visceral smooth muscle, consists of
single-unit smooth muscle, and cells response as a unit
in visceral smooth muscle, sheets of
spindle-shaped muscle fibers
in visceral smooth muscle, fibers held together by
gap junctions
in visceral smooth muscle, exhibit
rhythmicity
in visceral smooth muscle, conduct
peristalsis
in visceral smooth muscle, found in
walls of hollow organs
what is the more common type of smooth muscle?
visceral smooth muscle
like skeletal muscle contraction, smooth contraction features
interaction between actin and myosin
both use calcium and atp
both triggered by membrane impulses
unlike skeletal muscle , smooth muscle lacks
troponin, uses calmodulin instead
what two neurotransmitters affect smooth muscle?
Acetylcholine (ACh) and Norepinephrine (NE)
smooth muscle slower to
contract and relax
smooth muscle more resistant to
fatigue
cardiac muscle only located in
the heart
cardiac muscle appearance
striated muscle cells
cardiac muscle, muscle fibers jointed together by
intercalated discs
cardiac muscle, fibers branch and contain
a single nucleus
cardiac muscle,network of
fibers contract as a unit
cardiac muscle, are self-
exciting and rhythmic
cardiac muscle, has a longer ___ than sksletal muscle
refractory period
cardiac muscle, has no
sustained or tetanic contractions
major location of skeletal muscle?
skeletal muscles
major location of smooth muscle?
walls of hollow organs
major location of cardiac muscle?
wall of heart
major function of skeletal muscle?
movement of bones at joints, maintenance of posture
major function of smooth muscle?
movement of walls of hollow organs, peristalsis, vasoconstrction
major function of cardiac muscle
pumping action of the heart
are striations present in skeletal muscle?
yes
are striations present in smooth muscle
no
are striations present in cardiac muscle
yes
nucleus in skeletal muscle
multiple nuclei
nucleus in smooth muscle
single nucleus
nucleus in cardiac muscle
single nucleus
special features in skeletal muscle
transverse tubule system is well develooped
special features in smooth muscles
lacks transverse tubules
special features in cardiac muscles
transverse tubule system is well developed
4 basic components of levers?
Rigid bar or rod (bones)
Fulcrum or pivot on which bar moves (joint)
object moved against resistance (Weight)
force that supplies energy for movement (muscles)
what is the origin?
the less moveable end
what is the insertion
the more moveable end
When a muscle contracts, insertion is
pulled toward the origin
What is a agonist?
muscle that causes an action
what is a prime mover?
agonist primarily responsible for movement
what are syngerists?
muscles that assist agonst / prime movers
what are antagonists?
muscles whose contraction causes movement in the opposite direction of the prime mover
origin of epicranius?
occipital bone
epicranius - insertion?
skin around eye
epicranius - action?
elevates eyebrow as when surprised
epicranius - nerve supply
facial nerve
orbicularis oculi - origin
maxilla and frontal bone
orbicularis oculi - insertion
skin around eye
orbicularis oculi - action?
closes eyes as in blinking
orbicularis oculi - nerve supply?
facial nerve
orbicularis oris - origin
muscles near the mouth
orbicularis oris - insertion
skin of central lip
orbicularis oris - action
closes lips, protrudes lips as for kissing
orbicularis oris - nerve supply
facial nerve
buccinator - origin?
alveolar processes of maxilla and mandible
buccinator - insertion
orbicularis oris
buccinator - action
compresses cheek
buccinator - nerve supply
facial nerve
zygomaticus major - origin
zygomatic bone
zygomaticus major - insertion
skin and muscle at corner of mouth
zygomaticus major - action
elevates corner of mouth as when smiling
zygomaticus major - nerve supply
facial nerve
zygomaticus minor - origin
zygomatic
zygomaticus minor - insertion
skin and muscle at corner of mouth
zygomaticus minor - action
elevates corner of mouth as when smiling
zygomaticus minor - nerve supplyl
facial nerve
platysma - origin
fascia in upper chest
platysma - insertion
skin and muscles below mouth; mandible
platysma - action
depresses lower lip and angle of mouth as when pouting
platysma - nerve supply
facial nerve
masseter - origin
zygomatic arch
masseter - insertion
lateral surface of ramus of mandible
masseter - action
elevates and protracts mandible
masseter - nerve supply
trigeminal nerve
temporalis - origin
temporal bone
temporalis - insertion
coronoid process and anterior ramus of mandible
temporalis - action
elevates and retracts mandible
temporalis - nerve supply
trigeminal nerve
medial pterygoid - origin
sphenoid, palantine, and maxillary bone
medial pterygoid - insertion
medial surface of ramus of mandible
medial pterygoid - action
elevates mandible and moves it from side to side