ch 11 Flashcards
colonization
presence of microbes in host
infection
multiplication of organism in host
disease
when infection starts affecting host and causing damage
commensalism
microbe benefits and host is unaffected
mutualism
both benefit, host and microbe
parasitism
pathogens cause damage to host
sites where normal biota are found
skin, upper respiratory tract, vagina, external genitalia, external eyelids, GI tract, outer portion of urethra
sites where normal biota are not found
brain and blood stream
factors that weaken host defenses
–>old age, newborn
–>genetic defenses in immunity
–>surgery/transplants
–>diseases
–>chemotherapy
–>pregnancy
5 sources where newborn acquire microbiota
- in utero
- birth
- milk
- caregivers
- enviornment
pathogenicity vs virulence
pathogenicity: potential to cause disease
virulence: characteristics that contributes to ability cause damage
steps of a microbe must to take to cause disease
- portal of entry
- attach/negotiate with microbiome
- survive host defenses
- cause damage
- exit host
significance of polymicrobial infections
portals of entry
respiratory, gastrointestinal, genitourinary, skin, parenteral
portals of exit
respiratory secretions, feces, urine, blood, genital, secretions, wound exudates
infectious dose
minimum number of microbes necessary to cause an infection