CALCIUM Flashcards

1
Q

[?]most common element

A

5th

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

[?] of Ca in the human adult is ectracellular

A

~25 mol (1 kg)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

bones and teeth - most abundant

A

(99%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

as [?] - essential component of normal bone; makes up the bone mineral and matrix of the teeth

A

hydroxyapatite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

soft tissues and the ECF

A

(~1%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

CALCIUM

Skeleton
Soft tissues
ECF
Total

A

99%

1%

<0.2%

1000g (25 mol)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

PHOSPHATE

Skeleton
Soft tissues
ECF
Total

A

85%

15%

<0.1%

600g (19.4 mol)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

MAGNESIUM

Skeleton
Soft tissues
ECF
Total

A

55%

45%

1%

5g (1.0 mol)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

is protein bound

A

45%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

is bound to albumin

A

80%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

are bound to globulins

A

20%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

is complexed with high molecular weight molecules such as citrate and phosphate; lactate and bicarboante

A

10%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

are ionized/free or in their free form

A

45%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Primary hypoparathyroidism

A

Hypocalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Hypomagnesemia

A

Hypocalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Hypermagnesemia

A

Hypocalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Acute pancreatitis

A

Hypocalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Vit. D deficiency

A

Hypocalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Primary hyperparathyroidism –

A

Hypercalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

adenoma or glandular hyperplasia

A

Hypercalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Hyperthyroidism

A

Hypercalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Malignancy

A

Hypercalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Multiple myeloma

A

Hypercalcemia

24
Q

Increased Vit. D

A

Hypercalcemia

25
Q

Acidification of the sample (to dissociate Ca from proteins)

A

Dye-binding Methods

26
Q

Dye-binding Methods dyes

A

Ortho-cresolphthalein complexone (CPC)
Arsenazo III dye

27
Q

Uses 8-hydroxyquinoline to prevent mg interference

A

Ortho-cresolphthalein complexone (CPC)

28
Q

reference method for total Calcium

A
  1. AAS
29
Q

rarely used in the clinical setting

A
  1. AAS
30
Q

membrane that selectively, but reversibly bind Ca

A
  1. ISE
31
Q

Total Calcium - Serum, Plasma

A

2.15 - 2.5 mmol/L

32
Q

Ionized Calcium - Serum

A

1.16 - 1.32 mmol/L

33
Q

Ionized Calcium - Plasma

A

1.03 - 1.23 mmol/L

34
Q

Total Calcium 24 Hour Urine

A

2.5 - 7.5 mmol/day (100 - 300 mg/day)

35
Q

Total Ca

A

Serum or Li-H plasma (collected w/o stasis)

36
Q

Ionized Ca - samples collected anaerobically

A

heparinized blood

37
Q

timed collection; acidified w/ 6 mol/L HCl to prevent precipitation

A

Urine

38
Q

Regulation of cell functions

A

(inorganic messenger)

39
Q

Determines activity of several enzymes by combining w/ [?]

A

calmodulin

40
Q
  • small protein found in all nucleated cells
A

Calmodulin

41
Q

calcium-modulated protein

A

calmodulin

42
Q

type of Ca-binding protein found on the cell cytoplasm

A

calmodulin

43
Q

= acts as regulator

A

Ca + Calmodulin

44
Q

Regulates muscle contraction: binds to

A

troponin

45
Q

: Ca-binding protein subunit

A

Trop C

46
Q

not found in the heart but in the thin filaments or muscle

A

Trop C

47
Q

important for active muscle contraction

A

Trop C

48
Q

Ca stabilizes and hold contents

A

Regulates cell membrane permeability

49
Q

Controls secretions of some endocrine glands (?)

A

PT gland, Thyroid C cells

50
Q

PT gland:
Thyroid C cells:

A

PT hormone

Calcitonin

51
Q

Blood coagulation

A
52
Q

– first activated during tissue damage

A

Factor 3 (Thrombokinase)

53
Q

– reacts w/ Factor 3 to form Thrombin

A

Factor 2

54
Q

– converts fibrinogen to fibrin

A

Thrombin

55
Q

– makes up the mesh that makes up clot

A

Fibrin

56
Q

Rigidity to [?]

A

bones & teeth

57
Q

Lack of Ca: prone to

A

skeletal muscle disorders