Antenatal Screening Flashcards

1
Q

Organisation of a low risk pregnancy?

A
All care = midwive delivered 
US appointment at 8-12 weeks 
Review: 16 weeks 
Anomaly scan: 20 weeks (US)
Seen again: week 25,28,31,34,36 
If no delivery seen at: week 38,40,41,42
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2
Q

Organisation of high risk pregnancy?

A

Care led by consultant obstetrician

Appointment schedule is determined case to case

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3
Q

8-12 week scan with midwife looks at?

A

Full history
Height, weight, BP
Blood tests

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4
Q

Types of blood tests at 8-12 week booking scan with midwife?

A
Hb 
ABO 
Rhesus status and AB 
Syphilis 
HIV 
Hep B and C
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5
Q

When is most accurate time to confirm viability, gestational age and delivery date estimate?

A

Secondary appointment for US

Crown rump length (CRL) does estimated delivery date and gestational age

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6
Q

What if estimated gestational age is not done at weeks 8-12?

A

It is then estimated using head circumference which is less accurate

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7
Q

What is used prior to US to predict EDD?

A

Naegele’s rule

  • Based on onset of woman’s LMP add on 9 months 7 days to get due date
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8
Q

11 main conditions looked for in 20 week anomaly scan?

A
  • Anencephaly
  • Open spina bifida
  • Cleft lip
  • Diaphragmatic hernia
  • Gastrochisis
  • Exomphalos
  • Serious cardiac abnormalities
  • Bilateral renal agenesis
  • Lethal skeletal dysplasia
  • Edward’s syndrome
  • Patau’s syndrome
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9
Q

What is T18?

A

Edward’s syndrome

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10
Q

What is T13?

A

Patau’s

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11
Q

Trisomy risk assessment in 1st trimester involves what?

A

Measuring nuchal translucency

Combined with HCG and PAPP-A blood test to given a risk level that the baby has down’s

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12
Q

What can be screening for in 2nd trimster?

A

Only T21 not T18/13

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13
Q

What is NIPT?

A

Non-invasive prenatal testing
-This detects fetal DNA fragments in a sample of blood taken from mother and is more accurate than combined test so can be offered to women identified as high risk from combined test (although can’t offer TOP based on this result as only screening test)

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14
Q

What is done as diagnostic testing for trisomy and when?

A

Amniocentesis after 15 weeks
Miscarriage rate <1%

Chorionic villus sampling after 12 weeks
Miscarriage rate <2%

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15
Q

What deficiencies scanned for at booking scan?

A

Iron anaemia
Folate
B12

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16
Q

When should blood group and antibody status be determined in pregnancy?

A

At boking and 28 weeks to prevent fetal anaemia

17
Q

What can help prevent D antibodies forming in Rh -ve women and when?

A

Anti D injections

Routinely given at 28 weeks and after any sensitizing event

18
Q

Sensitizing events may include?

A
TOP 
Antepartum haemorrhage 
Invasive procedures 
External cephalic version 
Fall or accident
19
Q

What is given after birth of a baby who is Rh +ve?

A

Anti-D

20
Q

What tests is used to see if there is fetal blood in maternal circulation?

A

Kleihauer Betke test

Can tell if sensitizing event has happened

21
Q

What measurement is recomended at each antenatal appointment from 24 weeks?

A

Serial measurement of symphysis fundal height (SFH)

22
Q

What is placenta praevia?

A

When placenta is low lying in the uterus and covers all or part of the cervix
Site identified by anomaly scan

23
Q

If placenta has been low at anomaly scan?

A

Site is checked at 32 weeks gestation by US

24
Q

What are al of the different appointmnets?

A

Booking
20w
28w

25
Q

20 week scan looks for?

A
Cleft 
Heart 
NTD 
Limb defects 
Placental site 
Diaphragmic hernia
26
Q

28w scan looks for?

A

RC antibodies

Anaemia

27
Q

What do you measure in 1st trimester for trisomy screening?

A

Skin thickness behind foetal neck using US (Nuchal thickness NT)

28
Q

What is a normal NT?

A

<3.5mm should be considered normal when CRL is between 45 and 84mm

29
Q

What is NIPT?

A

Non-invasive prenatal testing

30
Q

What does NIPT detect?

A

Fetal DNA fragments in sample of blood from mother

31
Q

CffDNA detectable when?

A

From around 10 weeks f pregnancy and amount of detectable DNA thought to rise as pregnancy continues

32
Q

CffDNA stands for?

A

Cell free fetal DNA testing

33
Q

CffDNA is more or less dangerous than other testing?

A

Less

Doesn’t carry risk of miscarriage and can give parents to be higher quality ifo