A/62 Flashcards by Ines Crawford | Brainscape

Q

How many patients have adverse drug reactions?

A

7-8%

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Q

How many drug reactions prove fatal?

A

10%

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Q

Which adverse effect is the worst?

A

cardiac effect

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Q

Which drugs can cause arrythmias? (2)

A

theophylline

- hydantoins

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Q

Which drugs can cause cardiomyopathy? (2)

A

doxorubicin

- daunorubicin

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Q

2 drugs often found in overdose cases

A

aspirin

- acetaminophen

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Q

Effects of aspirin overdose

A

respiratory alkalosis and metabolic acidosis

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Q

How much aspirin is req to cause salicysm?

A

> 3mg daily

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Q

Symptoms of aspirin overdose (5)

A

headache
dizziness
tinnitus
mental confusion
nausea, vomiting

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Q

What causes death in aspirin overdose?

A

acute erosive gastritis

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Q

What causes acute erosive gastritis?

A

thromboxin blockage

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Q

What does acetaminophen overdose cause?

A

Centrilobular hepatic necrosis and liver failure

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Q

What did the thalidomid cause?

A

phocomelia

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Q

What test is used to assess mutagenic potential of chemical compounds?

A

ames test

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