A/39

Question 1

Which Ig is type 1 related to?

Answer 1

IgE

Question 2

What’s another name for type 1 hypersensitivity? (2)

Answer 2

reaginin type / anaphylactic

Question 3

3 phases of type 1 hypersensitivity

Answer 3

• initial phase
• early phase
• late phase

Question 4

Type 1 hypersensitivity primary mediators

Answer 4

histamine, serotonin, heparin (proteoglycans), chemotactil mediators

Question 5

Type 1 hypersensitivity secondary mediators

Answer 5

leukotrens, PGD2, cytokines (TNFalpha)

Question 6

3 consequences of type 1 hypersensitivity

Answer 6

• local anaphylaxis (atopic allergy)
• asthma bronchiale
• systemic anaphylaxis

Question 7

How much of the population has local anaphylaxis / allergy?

Answer 7

10% of the population

Question 8

Types of asthma bronchiale

Answer 8

• extrinsic (type 1 hypersens)

- intrinsic (not immune : due to stress, infection…)

Question 9

Features of asthma bronchiale (6)

Answer 9

• overinflated lungs
• mucus plugs (curschmann’s spiral)
• Eosinophil infiltration (charcot-leyden crystals)
• Infiltration of inflammatory cells
• Submucous gland hyperplasia
• Emphysema

Question 10

What is status asthmaticus?

Answer 10

difficult to release bronchospasm, permeability problem -> pulmonary edema

Question 11

Autopsy anaphylaxis signs (3)

Answer 11

• pulmonary edema
• hemorrhage
• right sided cardiac dilation

Question 12

What is type 2 hypersensitivity?

Answer 12

immune reaction against antigens fixed on cell surface

Question 13

4 ways of attacking in hypersensitivity type 2

Answer 13

1. opsonization
2. C5-C9 activation
3. Fc receptor mediated
4. TSH stimulation / block

Question 14

5 examples of type 2 hypersensitivity

Answer 14

• Rh incompatibility (erythroblastosis fetalis)
• Autoimmune hemolytic anaemia / agranulocytosis / thrombocytopenia
• Pernicious anemia
• Goodpasture syndrome
• Graves disease