A/29 Flashcards
1
Q
Causes of thrombus
A
- endothelial injury
- alteration of normal blood flow
- hypercoaguabiity
2
Q
2 types of endothelial injuries
A
- Loss of endothelium (diluting)
- Dysfunction of endothelium (non diluting)
3
Q
What can cause loss of endothelium? (3)
A
- hypertension
- turbulent flow
- bacterial endotoxins
4
Q
What can cause dysfunction of endothel? (3)
A
- hypercholesterol
- radiation
- smoking
5
Q
2 blood flow alterations
A
- turbulance
- stasis
6
Q
Clinical manifestations of altered blood flow
A
- aneurysm
- mitral valve stenosis
- atrial fibrillation
- hyperviscosity
7
Q
Types of hypercoagulability
A
- primary (inherited)
- secondary (acquired)
8
Q
Mutations that lead to hypercoagulability
A
- Factor 5 (Leiden) mutation
- Prothrombin gene mutation
9
Q
What can cause acquired hypercoagulability?
A
- oral contraceptives
- old age
- disseminated cancer
- smoking
- obesity
10
Q
How do contraceptives cause hypercoagulability?
A
increased hepatic synthesis of coagulation factors
11
Q
Morphology / types of thrombus (4)
A
- white thrombus
- red thrombus
- composit thrombus
- laminated thrombus
12
Q
What causes white thrombus?
A
endothelial injury or turbulance
13
Q
What is white thrombus made of?
A
fibrin and platelet
14
Q
Where does white thrombus develop?
A
arteries and heart
15
Q
Where does red thrombus develop?
A
veins
