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Pathology A > A/17 > Flashcards

A/17 Flashcards

1
Q

What is the precursor for melanine?

A

dihidroxiphenilalamine

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2
Q

How is dihidroxiphenilalamine produced?

A

thyrosinase in melanocytes transforms thyrosine

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3
Q

Histological detection of melanine?

A
  • v silver staining
  • S100 immunohistochemistry
  • H202 reaction
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4
Q

3 pathological changes of skin melanocytes

A
  • melasma
  • vitiligo
  • melanocytic nevi / nevus
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5
Q

What is melasma?

A

functional alteration of melanocytes that causes hyperproduction of melanin during pregnancy

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6
Q

Morphology of melasma

A

Hyperpigmentation, especially in the facial region, accelerated by the sun

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7
Q

What is vitiligo?

A

Partial or complete loss of pigment producing melanocytes

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8
Q

Difference between albinism and vitiligo?

A

In albinism the melanocytes are still present, but have no tyrosinase enzyme

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9
Q

Pathogenesis of vitiligo?

A

Autoimmunity - antibodies against melanocytes

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10
Q

What is the nevus?

A

Accumulation of melanocytes

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11
Q

3 morphologies of nevus

A
  • junctional
  • compound
  • dermal
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Pathology A (43 decks)

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