5.2 Pulmonary Flashcards
for gas exchange to occur, we must have WHAT at same place?
1) ventilation (air)
2) perfusion (blood)
what is pulmonary vascular resistance?
the resistance to blood flow going thru pulmonary circulation AND how it is related to R ventricular cardiac output
what happens as R. ventricular output increases? (pumps more out)
resistance to outflow in pulmonary vasculature goes down
the more blood that goes into pulmonary vasculature, the ____ resistance to blood flow
less
as more blood goes into pul. vessels, why does resistance go down?
1) resistance in parallel add receprically
- -so when you have an increae inparallel pathways, total resistance goes down
2) increase in R. cardiac output bc they can distend ( or increase their vessel radius)
increasing cardiac output ____ resistance to bloodflow
decreases
what is physiological dead-space?
anatomic + alveolar deadspace
define alveolar dead-space?
- ventilation but no perfusion
* wasted gas in alveolar, typically due to a clot stopping blood flow
define anatomic dead-space?
conducting pathways blocked so no gas exchange
1) what happens if you have both ventilation and perfusion at same spot?
2) one and not the other?
3) both at different spots?
1) Gas exchange!
2) no gas exchange
3) no has exchange
how can you get vent and perfusion mismatch?
- clots and embolace = vent and no per
* mucus plug or objects inwindpipe= per but no vent
how much alveolar dead-space is in a healthy person?
very very low
what does your body do to an area of no gas exchange over a long period of time?
brachioconstriction!
bc why support air if there is no exchange
what is L to R shunting?
- impacts large area of blood
- when R deoxygenated blood dumps right into the L ventricle
- low O2 and high CO2 in blood
what is hypoxic pulmonary vasoconstriction
something is blocking an airway and you do NOT have ventilation (become hypoxic)
define hypoxic
can’t get enough oxygen
what happens with no ventilation?
O2 keeps getting used but NOT resupplied. So alveolar gas becomes hypoxic and sends a signal to the upstream vessel to vasoconstrict
*hypoxic pulmonary vasoconstriction response
body response to an area of no ventilation?
decrease perfusion
is hypoxic pulmonary vasoconstriction a normal response?
Yes!
*segmented effect
when is hypoxic pulmonary vasoconstriction NOT a normal response?
high altitude with lower partial pressure of oxygen in the atmosphere. This can lead all of your alveolar to read as ‘hypoxic’ thus causing constriction
- global effect
- increase altitude= decrease partial pressure of oxygen