1.2 Phys gradients Flashcards

1
Q

gradients

A

when a difference exists between two compartments with respect to the pressure, conc, or electrical potential of a given variable

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2
Q

3 types gradients?

Examples?

A

1) pressure= fluid moves from high pressure to low
2) concentration= K+ and Na+
3) electrical= membrane potentials
* **energy

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3
Q

Gradients are a source of? Cells spend a lot of ____ controlling gradients?

A

energy

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4
Q

**conc gradients of Na+ and K+

A
150 outside (ECF= Na); 140 inside (ICF=K+)
*ocean banana*
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5
Q

membrane potential is another way of saying?

A

electrical gradient

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6
Q

membrane function and examples?

A

1) membrane dynamics= transport, translation, signal transduction
2) membrane potentials= graded, action, equilibrium, receptor

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7
Q

membrane structure?

A

bilayer lipid barrier

1) repels hydrophilic/lipophobic/polar/charges
2) admits hydrophobic/lipophilic/nonpolar/uncharged

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8
Q

communication across membrane (3)

A

1) membrane transport proteins= selectivity =specific
2) membrane translocation channels= selectivity; pass ions
3) signal transduction processes= INFO ONLY passes

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9
Q

hydrophobic affect with transport channels

A

nonpolar outside and polar inside

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10
Q

outer leaflet and inner leaflet of phospholipid bilayer

A

outer=sphingomyelin and phosphatidylcholine

inner= phosphotidylcholine, P serine, P inositol

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11
Q

amphipathic

A

having both hydrophilic and hydrophobic parts

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12
Q

determinants for what crosses?

A

!) polarity

2) lipid solubility
3) size
* charged molecules like to hang out with charged molecules and repel neutral
* neutral like neutral and repel charged

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13
Q

charged heads of lipid bilayer do not provide much of a barrier for?

A

neutral molecules

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14
Q

H2O is polar or non?

permeable bc of?

A
  • polar/charged/hydrophilic/lipophobic

* aquaporins

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15
Q

what are aquaporins

A

membrane translocation proteins selective for WATER and bidirectional

  • water cannot cross by itself, NEEDED
  • amount depends on cell
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16
Q

description for charged molecules?

A
POLAR
hydrophilic
lipophobic
CANNOT cross freely
*ions, glucose, AA, neurotransmitter
17
Q

description for UNcharged molecules? (aka neutral)

A
NONPOLAR
hydrophobic
lipophilic
CAN cross freely
*FA, cholesterol, steroid hormones, O2, CO2
18
Q

increaseing concentration always increases?

A

rate of diffusion

19
Q

passive transport process? (2)

hydro or lipophilic?

A

1) diffusion or simple diffusion =lipophilic
2) facilitated diffusion =hydrophilic
* no ATP energy required

20
Q

active transport processes? (2)

A

1) primary active transport
2) secondary active
* ATP energy required

21
Q

what transport processes are mediated transport?

A

1) facilitated (passive)
2) primary active transport (active)
3) secondary active transport (active)

22
Q

influx vs efflux vs net flux

A

influx= into cell
efflux= exit cell
net flux= there is ALWAYS movement both directions, depends on what one is more

23
Q

what is inversely related to diffusion rate?

A

thickness of diffusion barrier

24
Q

what is directly related to diffusion rate?

A

surface area available for diffusion
diffusivity of solute= lipid solubility
concentration of solute

25
Q

osmosis vs aquaporins

A
osmosis= simply water moving from area of high to low
*aquaporins= SUPPORT osmosis, they are NOT carriers; simply proteins with channels
26
Q

supplemental oxygen and exercise increases or decreases?

A

increase rate of diffusion

27
Q

signal transduction pathways initiated by lipid-soluble messengers CAN or CANNOT cross plasma membrane? Ex?

A

CAN

*steroid, thyroid hormones, vit D

28
Q

signal transduction pathways initiated by water-soluble messengers CAN or CANNOT cross plasma membrane? Ex?

A

CANNOT

*membrane signal transduction; peptide hormones, cytokines, neurotransmitters, growth factors

29
Q

pathways initiated by lipid-soluble messengers will then engage a receptor in the ____ or ____? associated with?

A

cytosol or nucleus

*associated with making new proteins, takes time

30
Q

pathways initiated by water-soluble messengers are fast or slow? Ex?

A

fast

*cAMP, IP3

31
Q

At rest extracellular fluid is?

A

0 mV

Intracellular is -