5.1 Diseases associated with defects in phagocytosis and APR

Question 1

an Inherited disease where Impaired NADPH production but can Still INGEST but not kill

a. Chronic Granulomatous Disease
b. Lazy Leukocyte syndrome
c. Job’s Syndrome / Buckley Syndrome

Answer 1

a

Question 2

In Chronic Granulomatous disease, what is the test?

Answer 2

Nitroblue Tetrazolium test

Question 3

Results for Nitroblue tetrazolium Test?

Answer 3

Blue - Indicates normal

No - Indicates CGD

Question 4

Other test for CGD are:

• Neutrophil Oxidative burst assay which is a ____________ flow cytometry

Answer 4

Semi Quantitative

Question 5

Hyper IgE syndrome

a. Chronic Granulomatous Disease
b. Lazy Leukocyte syndrome
c. Job’s Syndrome / Buckley Syndrome

Answer 5

c

Question 6

Impaired Recruitment / chemotaxis of neutrophils due to decreased production of IFN-gamma by T cells

a. Chronic Granulomatous Disease
b. Lazy Leukocyte syndrome
c. Job’s Syndrome / Buckley Syndrome

Answer 6

c

Question 7

Defect in Neutrophil chemotaxis

a. Chronic Granulomatous Disease
b. Lazy Leukocyte syndrome
c. Job’s Syndrome / Buckley Syndrome

Answer 7

b

Question 8

Has lesions which is atopic dermetitis and can have recurrent infection

a. Chronic Granulomatous Disease
b. Lazy Leukocyte syndrome
c. Job’s Syndrome / Buckley Syndrome

Answer 8

c

Question 9

Plasma proteins that are increased rapidly in response to innate for inflammation

Answer 9

Acute phase reactants

Question 10

APR are produced by what organ?

Answer 10

Liver

Question 11

What is the protein (APR) of this?

Response time: 4-6
Normal Concentration: 0.5
Increase: 1000x
Function: Opsonization, complement activation

a. C-reactive protein
b. Serum amyloid A
c. Alpha, antitrypsin
d. Fibrinogen

Answer 11

a

Question 12

What is the protein (APR) of this?

Response time: 24
Normal Concentration: 5
Increase: 1000x
Function: Activates monocytes and macrophage

a. C-reactive protein
b. Serum amyloid A
c. Alpha, antitrypsin
d. Fibrinogen

Answer 12

b

Question 13

What is the protein (APR) of this?

Response time: 24
Normal Concentration: 200-400
Increase: 2-5x
Function: Protease inhibitor

a. C-reactive protein
b. Serum amyloid A
c. Alpha, antitrypsin
d. Fibrinogen

Answer 13

c

Question 14

What is the protein (APR) of this?

Response time: 24
Normal Concentration: 200-400
Increase: 2-5x
Function: Clot formation

a. C-reactive protein
b. Serum amyloid A
c. Alpha, antitrypsin
d. Fibrinogen

Answer 14

d

Question 15

What is the protein (APR) of this?

Response time: 24
Normal Concentration: 40-290
Increase: 2-10x
Function: Binds hemoglobin

a. Haptoglobin
b. Ceruloplasmin
c. Complement C3

Answer 15

a

Question 16

What is the protein (APR) of this?

Response time: 48-72
Normal Concentration: 60-140
Increase: 2x
Function: Opsonization, lysis

a. Haptoglobin
b. Ceruloplasmin
c. Complement C3

Answer 16

c

Question 17

What is the protein (APR) of this?

Response time: 48-72
Normal Concentration: 20-40
Increase: 2x
Function: Binds copper and oxidizes iron

a. Haptoglobin
b. Ceruloplasmin
c. Complement C3

Answer 17

b

Question 18

Which APR can be an indicator of acute inflammation

Answer 18

C-reactive protein

Question 19

C-reactive protein is a surrogate marker of IL__

Answer 19

6

Question 20

Which protein is cytokine like activity?

Answer 20

Serum amyloid A

Question 21

Most abundant Complement

Answer 21

C3