14.1 Properties of Immunoglobulins Flashcards
5 ab classes are base on light or heavy chain?
Heavy
Heaviest and the largest molecular weight
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
b
Longest half life in the serum sample
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
a
Smallest molecular weight
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
a
Smallest molecular weight in monomeric form
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
c
The least half life in Ab
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
d
Most abundant Ab in serum
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
a
Least abundant Ab
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
e
Has a constant domain of 4
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
b and e
Has constant domain of 3
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
a c d
Able to activate complement (Complement Fixation)
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
a and b
Most affective in Complement fixation
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
a
Crosses placenta
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
a
IgM can be monomeric which can be seen on the surface of a B cell and pentameric on Serum
T or F
T
IgA can be monomer and a Dimer
T or F
T
IgD and IgE are only Monomer
T or F
T
The most abundant IgG subclass
IgG1
(1,2,3,4)
The least abundant IgG subclass
IgG4
Subclass of IgG that can cross the placenta
IgG 1,3,4
Subclass of IgG that the most effective Complement activator
IgG3
Subclass of IgG that is effective in opsonization
IgG1
IgG3
IgG4 cant fix complement
T or f
T
IgG2 CAN cross the placenta
T or F
F
Cannot
An incomplete Ab that provides immunity to newborn and can do opsonization, neutralization of toxins and viruses
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
a
Also known as Mucosal paint
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
c
Found in the surface of B cell or Marker of Mature B cell
Immunoregulator membrane Ig
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
d
A pentameric
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
b
Most primitive, agglutination, opsonization and neutralization
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
b
A Reaginic Ab that is involved in atopic / allergic reaction, parasite and majority of it are attach to mast cells
a. IgG
b. IgM
c. IgA
d. IgD
e. IgE
e
IgE are Heat labile
T or F
T
Immuno-competent cells have surace receptors that are capable of reaction with antigens, which have complementary side chains to which the specific antigen fit complementarily
a. Side chain theory
b. Clonal Selection theory
a
Who proposed side chain theory?
Ehrlich (1898)
Lymphocytes are preprogrammed to produce one type of Ig and a particular cell is capable of responding to it, causing it to proliferate
a. Side chain theory
b. Clonal Selection theory
b
Hybridoma technology is the production of polyclonal antibodies
T or F
F
Monoclonal
In hybridoma technology, Ab is usually produce from what animal
Mices
What is being harvested in the mice after Ab-Ag reaction?
Spleen
This component fuse Ag-Ab in Hybridoma technology
HGPRT
T cell receptor composed of 2 polypeptide chains which are alpha and beta
T or F
T
Ag specific component:
Surface immunoglobulin
a. T cell receptor
b. B cell receptor
b
Ag specific component:
Heterodimar alpha-beta / delta, gamma
a. T cell receptor
b. B cell receptor
a
Receptor Valence:
Bivalent
a. T cell receptor
b. B cell receptor
b
Receptor Valence:
Monovalent
a. T cell receptor
b. B cell receptor
a
Isotype switching
a. T cell receptor
b. B cell receptor
b
