12.1 Major Histocompatibility complex (MHC) Flashcards
MHC is discovered as a genetic locus that determines acceptance or rejection of tissue grafts exchange between persons
T or F
T
MHC _____ plays an important role in graft survival
Proteins
Without the MHC, the antigen will not be recognized by the T cell
T or F
T
Membrane proteins present on APCs that display processed antigens to be recognized by ______ cells
T cells
Human Leukocyte antigen - Human MHC
NOTE
Cellular distribution:
Antigen-presenting cells (B cells, Monocytes, Macrophages, dendritic cells, thymic, epithelial cells)
a. Class I MHC
b. Class II MHC
b
Major APC?
Dendritic cells
All Nucleated Cells contains what MHC?
MHC Class I
Structure
One alpha chain and B2-microglobulin
a. Class I MHC
b. Class II MHC
a
Structure
alpha chain and beta chain
a. Class I MHC
b. Class II MHC
b
Classes
DP, DQ, DR
a. Class I MHC
b. Class II MHC
b
Classes
A, B, C
a. Class I MHC
b. Class II MHC
a
Size of peptides:
8 to 11 amino acids
a. Class I MHC
b. Class II MHC
a
Size of peptides:
13 to 18 amino acids
a. Class I MHC
b. Class II MHC
b
Nature of peptide binding cleft:
open at both ends
a. Class I MHC
b. Class II MHC
b
Nature of peptide binding cleft:
Closed at both ends
a. Class I MHC
b. Class II MHC
a
Interaction with T cells:
Presents ENDOGENOUS antigens to CD8 T cells
a. Class I MHC
b. Class II MHC
a
Interaction with T cells:
Presents EXOGENOUS antigens to CD4 T cells
a. Class I MHC
b. Class II MHC
b
This MHC class include complement proteins, TNF, Alpha and Beta, and other proteins
MHC class III
CLASS III MHC is associated with cell membrane surfaces
T or F
F
Not associated
HLA:
Strongest link to Ankylosing spondylitis
a. HLA B8
b. HLA-DR2
c. HLA-B27
d. HLA-DR5
c
HLA:
Graves disease and DM type 1
a. HLA B8
b. HLA-DR2
c. HLA-B27
d. HLA-DR5
a
HLA:
Chronic lymphatic leukemia; Kaposi sarcoma (Mediterranean)
a. HLA B8
b. HLA-DR2
c. HLA-B27
d. HLA-DR5
d
HLA:
Rheumatoid arthritis, DM type 1, pemphigus vulgaris
a. HLA B2
b. HLA-DR4
c. HLA-B7
d. HLA-DR5
b
Bga: HLA B7
Bgb: HLA B17
Bgc: HLA A28
T or F
T
What compromises the peptide binding groove/cleft of class II?
beta I and alpha I
What compromises the peptide binding groove/cleft of class I?
Alpha 2 and alpha 1
