12.1 Major Histocompatibility complex (MHC)

Question 1

MHC is discovered as a genetic locus that determines acceptance or rejection of tissue grafts exchange between persons

T or F

Answer 1

T

Question 2

MHC _____ plays an important role in graft survival

Answer 2

Proteins

Question 3

Without the MHC, the antigen will not be recognized by the T cell

T or F

Answer 3

T

Question 4

Membrane proteins present on APCs that display processed antigens to be recognized by ______ cells

Answer 4

T cells

Question 5

Human Leukocyte antigen - Human MHC

NOTE

Question 6

Cellular distribution:

Antigen-presenting cells (B cells, Monocytes, Macrophages, dendritic cells, thymic, epithelial cells)

a. Class I MHC
b. Class II MHC

Answer 6

b

Question 7

Major APC?

Answer 7

Dendritic cells

Question 8

All Nucleated Cells contains what MHC?

Answer 8

MHC Class I

Question 9

Structure

One alpha chain and B2-microglobulin

a. Class I MHC
b. Class II MHC

Answer 9

a

Question 10

Structure

alpha chain and beta chain

a. Class I MHC
b. Class II MHC

Answer 10

b

Question 11

Classes

DP, DQ, DR

a. Class I MHC
b. Class II MHC

Answer 11

b

Question 12

Classes

A, B, C

a. Class I MHC
b. Class II MHC

Answer 12

a

Question 13

Size of peptides:

8 to 11 amino acids

a. Class I MHC
b. Class II MHC

Answer 13

a

Question 14

Size of peptides:

13 to 18 amino acids

a. Class I MHC
b. Class II MHC

Answer 14

b

Question 15

Nature of peptide binding cleft:

open at both ends

a. Class I MHC
b. Class II MHC

Answer 15

b

Question 16

Nature of peptide binding cleft:

Closed at both ends

a. Class I MHC
b. Class II MHC

Answer 16

a

Question 17

Interaction with T cells:

Presents ENDOGENOUS antigens to CD8 T cells

a. Class I MHC
b. Class II MHC

Answer 17

a

Question 18

Interaction with T cells:

Presents EXOGENOUS antigens to CD4 T cells

a. Class I MHC
b. Class II MHC

Answer 18

b

Question 19

This MHC class include complement proteins, TNF, Alpha and Beta, and other proteins

Answer 19

MHC class III

Question 20

CLASS III MHC is associated with cell membrane surfaces

T or F

Answer 20

F

Not associated

Question 21

HLA:

Strongest link to Ankylosing spondylitis

a. HLA B8
b. HLA-DR2
c. HLA-B27
d. HLA-DR5

Answer 21

c

Question 22

HLA:

Graves disease and DM type 1

a. HLA B8
b. HLA-DR2
c. HLA-B27
d. HLA-DR5

Answer 22

a

Question 23

HLA:

Chronic lymphatic leukemia; Kaposi sarcoma (Mediterranean)

a. HLA B8
b. HLA-DR2
c. HLA-B27
d. HLA-DR5

Answer 23

d

Question 24

HLA:

Rheumatoid arthritis, DM type 1, pemphigus vulgaris

a. HLA B2
b. HLA-DR4
c. HLA-B7
d. HLA-DR5

Answer 24

b

Question 25

Bga: HLA B7
Bgb: HLA B17
Bgc: HLA A28

T or F

Answer 25

T

Question 26

What compromises the peptide binding groove/cleft of class II?

Answer 26

beta I and alpha I

Question 27

What compromises the peptide binding groove/cleft of class I?

Answer 27

Alpha 2 and alpha 1