17.1 Hypersensitivity reaction Flashcards
Hypersensitivity reactions is a:
Heightened state or immune response
EXAggerated response to a harmful antigen that result to an injury in the tissue, disease, or even death
T or F
F
Harmless
NOTE: in remembering the 4 types of hypersensitivity:
ACID (Type 1,2,3,4)
What type of hypersensitivity is anaphylactic?
Type I
What type of hypersensitivity is Cytotoxic?
Type II
What type of hypersensitivity is the Immune complex?
Type III
What type of hypersensitivity is Delayed?
Type IV
Type I immune mediators?
IgE
Type IV immune mediators?
T cells
Type III immune mediators?
IgG or IgM
Type II immune mediators?
IgM and IgG
Antigens involve for this type is heterologous
Type I
Antigens involve for this type is Autologous and Heterologous on cell surface
Type II
Antigens involve for this type is heterologous and autologous on soluble antigen
Type III
Antigens involve for this type is heterologous and autologous
Type IV
What type of hypersensitivity involves complement?
II and III
Type of hypersensitivity:
Cell destruction by antibody and complement opsonization or ADCC
Type II
Type of hypersensitivity:
Release of mediators from IgE-sensitized mast cells and basophils
Type I
Type of hypersensitivity:
Antigen-antibody complexes activate complement proteins
Type III
Type of hypersensitivity:
Antige-sensitized Th1 cells release cytokine that recruits macrophages and induces inflammation or activates T cells to cause direct cell
Type IV
Clinical examples for Hypersensitivity:
Contact dermatitis tuberculin, and energy skin tests
Type IV
Clinical examples for Hypersensitivity:
Transfusion reactions.
Type II
Clinical examples for Hypersensitivity:
Myasthenia gravis, Goodpasture’s syndrome, Graves disease
Type II
Clinical examples for Hypersensitivity:
Serum sickness, Arthus reaction
Type III
Clinical examples for Hypersensitivity:
Lupus erythematosus, rheumatoid arthritis, drug reaction
Type III
Clinical examples for Hypersensitivity:
Anaphylaxis, allergic rhinitis, allergic asthma
Type I
Tests for hypersensitivity:
In-Vivo skin test
a. Type I
b. Type II
c. Type III
d. Type IV
a
Tests for hypersensitivity:
Radioimmunosorbent test and Radioallergosorbent test
a. Type I
b. Type II
c. Type III
d. Type IV
a
RIST assess allergen Specific IgE
RAST assess Total IgE
T or F
F
Blaigtad
Tests for hypersensitivity:
Detection of Cold agglutinin
a. Type I
b. Type II
c. Type III
d. Type IV
b
Tests for hypersensitivity:
Coomb’s test (DAT, IAT)
a. Type I
b. Type II
c. Type III
d. Type IV
b
DAT detects in vivo sensitization
IAT detects in vitro sensitization
T or F
T
Tests for hypersensitivity:
Mantoux test (Tuberculin test)
a. Type I
b. Type II
c. Type III
d. Type IV
d
Tests for hypersensitivity:
Measurement of complement levels
a. Type I
b. Type II
c. Type III
d. Type IV
c
Tests for hypersensitivity:
Detection of anti-nuclear antibodies
a. Type I
b. Type II
c. Type III
d. Type IV
c
Tests for hypersensitivity:
Raji Cell Assay
a. Type I
b. Type II
c. Type III
d. Type IV
c
