18.1 Tumor immunology

Question 1

Tumors are abnormal mass of tissue; which is also known as?

Answer 1

Neoplasm

Question 2

Neoplasm is compromised of 2 components:

P______
S_______

Answer 2

Parenchyma
Stroma

Question 3

Proliferating cells

a. Parenchyma
b. Stroma

Answer 3

a

Question 4

Supporting cells

a. Parenchyma
b. Stroma

Answer 4

b

Question 5

Study of tumors

Answer 5

Oncology

Question 6

More Differentiated (More normal looking)

a. Benign
b. Malignant

Answer 6

a

Question 7

Less differentiated, Cancer

a. Benign
b. Malignant

Answer 7

b

Question 8

Malignant tumor are capable of M_________

Answer 8

metastasis

Question 9

Lab detection of tumors:

• Gross and microscopic morphology
• IHC or automated immunoassay
• Molecular method

Which doe not belong?

Answer 9

None

Question 10

Gold standard for detecting/identifying tumors

Answer 10

Biopsy

Question 11

Biological substances that are found in increased amounts in the blood, body fluids, or tissues or patients with a specific type of cancer

Answer 11

Tumor markers

Question 12

Tumor marker in itself are not definitive and requires more testing

T or F

Answer 12

T

Question 13

4 major clinical classification of tumor markers:

Sc______
Di_____
Pr_____
Mo______

Answer 13

Screening
Diagnostic
Prognostic
Monitoring

Question 14

Virus that can cause Burkitt lymphoma, Hodgekin lymphoma

Answer 14

EBV

Question 15

Which among Hepa B or C has the higher risk of hepatocellular carcinoma?

Answer 15

C

Question 16

What virus can cause Kaposi sarcoma?

Answer 16

HIV

Question 17

Virus that can cause Cervical Cancer. and other genital cancer

Answer 17

Human papilloma Virus

Question 18

Virus that can cause Adult T-cell leukemia or lymphoma

Answer 18

Human T-lymphotropic virus

Question 19

Merkel cell Carcinoma (Skin cancer

Answer 19

Merkel Cell polymavirus

Question 20

Cell surface markers include estrogen and progesterone receptors CD markers on WBC which is a prognosis from hormone therapy in ________ cancer

Answer 20

Breast

Question 21

Proteins Tumor markers:

Well-differentiated papillary or follicular thyroid carcinoma

Answer 21

Thyroglobulin

Question 22

Proteins Tumor markers:

Multiple myeloma and lymphoid malignancies

Answer 22

Ig and Ig light chains (Bence Jones proteins)

Question 23

Oncofetal antigens:

Germ cell carcinomas

Answer 23

Alpha-fetoprotein

Question 24

Oncofetal antigens:

Colorectal cancer

Answer 24

Carcinoembryonic antigen

Question 25

CHO antigens:

CA125

Answer 25

Ovarian cancer

Question 26

CHO antigens:

CA15-3

Answer 26

Breast cancer

Question 27

CHO antigens:

CA19-9

Answer 27

Pancreatic and gastrointestinal cancer

Question 28

Enzymes and Isoenzymes:

Prostate cancer

Answer 28

Prostate-specific antigen

Question 29

Enzymes and Isoenzymes:

Elevates in pancreatic tumor

Answer 29

Prostate-Specific antigen (PSA)

Question 30

Enzymes and Isoenzymes:

Bone and liver cancer

Answer 30

Alkaline phosphatase

Question 31

Enzymes and Isoenzymes:

Neural tissue neoplasms

Answer 31

Neuron-specific enolase

Question 32

Hormones:

Germ cell carcinoma, trophoblastic tumors

a. Human chorionic gonadotropin
b. Calcitonin
c. Gastrin

Answer 32

a

Question 33

Hormones:

Medullary thyroid cancer

a. Human chorionic gonadotropin
b. Calcitonin
c. Gastrin

Answer 33

b

Question 34

Hormones:

Pancreatic cancer

a. Human chorionic gonadotropin
b. Calcitonin
c. Gastrin

Answer 34

c