10.1 Complement Flashcards

1
Q

Complement aka “A____”

A

Alexin

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2
Q

Complement are a set of Heat stable serum proteins normally present in serum

T or F

A

F

Heat labile

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3
Q

Complement are produce by what organ?

A

Liver

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4
Q

Factor D is produced by in?

A

Adipocyte

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5
Q

Complement are active precursors and acts as a cascade

T or F

A

F

inactive

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6
Q

Function of Complement:

L___
O_________
Activation if I________
Clearance of immune complexes

A

Lysis
Opsonization
Inflammation

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7
Q

Effector functions of COmplement:

Chemotaxins:

a. C5a, C5b
b. C6
c. C7
d. C3a

Which of the following does not belong?

A

d

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8
Q

What complement is for immune adherence?

A

C3b

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9
Q

What is the largest complement?

A

C1

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10
Q

What complement is for kinin activator?

A

C2b

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11
Q

Effector functions of COmplement:

Anaphylatoxins

a. C4a
b. C5a
c. C2b
d. C3a

Which of the following does not belong?

A

c

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12
Q

Most abundant Complement

A

C3

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13
Q

Effector functions of COmplement:

Opsonins

a. C5b
b. C4a
c. C4b
d. C3b

Which of the following does not belong?

A

b

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14
Q

Effector functions of COmplement:

For virus neutralization:

a. C5a
b. C4b
c. C1
d. C3a

Which of the following does not belong?

A

a and d

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15
Q

Effector functions of COmplement:

Cell lysis

a. C5b
b. C9
c. C7
d. C3a

Which of the following does not belong?

A

d

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16
Q

Activating Sub.:

Mannose groups on microbial cell

a. Classical
b. Alternative (Properdin)
c. Lectin

17
Q

Activating Sub.:

Immune complexes (2 IgG / IgM)

a. Classical
b. Alternative (Properdin)
c. Lectin

18
Q

Activating Sub.:

LPS, fingal cell walls, yeast, viruses tumor cells

a. Classical
b. Alternative (Properdin)
c. Lectin

19
Q

Activating Sub.:

IgA

a. Classical
b. Alternative (Properdin)
c. Lectin

20
Q

In classical pathway, IgG requires more than 2 to be activated

T or F

21
Q

Recognition unit:

C1q, C1r, C1s

a. Classical
b. Alternative (Properdin)
c. Lectin

22
Q

Recognition unit:

MBP, MASP-1, MASP2

a. Classical
b. Alternative (Properdin)
c. Lectin

23
Q

Recognition unit:

C3, Factor B, Factor D

a. Classical
b. Alternative (Properdin)
c. Lectin

24
Q

C3 Convertase

C4b2a

a. Classical
b. Alternative (Properdin)
c. Lectin

25
C3 Convertase C3bBb a. Classical b. Alternative (Properdin) c. Lectin
b
26
C5 Convertase C4b2a3b a. Classical b. Alternative (Properdin) c. Lectin
a and c
27
C5 Convertase C3bBb3b a. Classical b. Alternative (Properdin) c. Lectin
b
28
MAC: C5b6789 a. Classical b. Alternative (Properdin) c. Lectin
All of the above
29
C3bBb a. C3 Convertase b. C5 convertase
a
30
C4b2b a. C3 Convertase b. C5 convertase
a
31
C3bBb3b a. C3 Convertase b. C5 convertase
b
32
C4b2b3b a. C3 Convertase b. C5 convertase
b
33
What is the end result of all pathways?
Cell lysis