10.1 Complement Flashcards
Complement aka “A____”
Alexin
Complement are a set of Heat stable serum proteins normally present in serum
T or F
F
Heat labile
Complement are produce by what organ?
Liver
Factor D is produced by in?
Adipocyte
Complement are active precursors and acts as a cascade
T or F
F
inactive
Function of Complement:
L___
O_________
Activation if I________
Clearance of immune complexes
Lysis
Opsonization
Inflammation
Effector functions of COmplement:
Chemotaxins:
a. C5a, C5b
b. C6
c. C7
d. C3a
Which of the following does not belong?
d
What complement is for immune adherence?
C3b
What is the largest complement?
C1
What complement is for kinin activator?
C2b
Effector functions of COmplement:
Anaphylatoxins
a. C4a
b. C5a
c. C2b
d. C3a
Which of the following does not belong?
c
Most abundant Complement
C3
Effector functions of COmplement:
Opsonins
a. C5b
b. C4a
c. C4b
d. C3b
Which of the following does not belong?
b
Effector functions of COmplement:
For virus neutralization:
a. C5a
b. C4b
c. C1
d. C3a
Which of the following does not belong?
a and d
Effector functions of COmplement:
Cell lysis
a. C5b
b. C9
c. C7
d. C3a
Which of the following does not belong?
d
Activating Sub.:
Mannose groups on microbial cell
a. Classical
b. Alternative (Properdin)
c. Lectin
c
Activating Sub.:
Immune complexes (2 IgG / IgM)
a. Classical
b. Alternative (Properdin)
c. Lectin
a
Activating Sub.:
LPS, fingal cell walls, yeast, viruses tumor cells
a. Classical
b. Alternative (Properdin)
c. Lectin
b
Activating Sub.:
IgA
a. Classical
b. Alternative (Properdin)
c. Lectin
b
In classical pathway, IgG requires more than 2 to be activated
T or F
T
Recognition unit:
C1q, C1r, C1s
a. Classical
b. Alternative (Properdin)
c. Lectin
a
Recognition unit:
MBP, MASP-1, MASP2
a. Classical
b. Alternative (Properdin)
c. Lectin
c
Recognition unit:
C3, Factor B, Factor D
a. Classical
b. Alternative (Properdin)
c. Lectin
b
C3 Convertase
C4b2a
a. Classical
b. Alternative (Properdin)
c. Lectin
a and c
C3 Convertase
C3bBb
a. Classical
b. Alternative (Properdin)
c. Lectin
b
C5 Convertase
C4b2a3b
a. Classical
b. Alternative (Properdin)
c. Lectin
a and c
C5 Convertase
C3bBb3b
a. Classical
b. Alternative (Properdin)
c. Lectin
b
MAC:
C5b6789
a. Classical
b. Alternative (Properdin)
c. Lectin
All of the above
C3bBb
a. C3 Convertase
b. C5 convertase
a
C4b2b
a. C3 Convertase
b. C5 convertase
a
C3bBb3b
a. C3 Convertase
b. C5 convertase
b
C4b2b3b
a. C3 Convertase
b. C5 convertase
b
What is the end result of all pathways?
Cell lysis
