10.1 Complement

Question 1

Complement aka “A____”

Answer 1

Alexin

Question 2

Complement are a set of Heat stable serum proteins normally present in serum

T or F

Answer 2

F

Heat labile

Question 3

Complement are produce by what organ?

Answer 3

Liver

Question 4

Factor D is produced by in?

Answer 4

Adipocyte

Question 5

Complement are active precursors and acts as a cascade

T or F

Answer 5

F

inactive

Question 6

Function of Complement:

L___
O_________
Activation if I________
Clearance of immune complexes

Answer 6

Lysis
Opsonization
Inflammation

Question 7

Effector functions of COmplement:

Chemotaxins:

a. C5a, C5b
b. C6
c. C7
d. C3a

Which of the following does not belong?

Answer 7

d

Question 8

What complement is for immune adherence?

Answer 8

C3b

Question 9

What is the largest complement?

Answer 9

C1

Question 10

What complement is for kinin activator?

Answer 10

C2b

Question 11

Effector functions of COmplement:

Anaphylatoxins

a. C4a
b. C5a
c. C2b
d. C3a

Which of the following does not belong?

Answer 11

c

Question 12

Most abundant Complement

Answer 12

C3

Question 13

Effector functions of COmplement:

Opsonins

a. C5b
b. C4a
c. C4b
d. C3b

Which of the following does not belong?

Answer 13

b

Question 14

Effector functions of COmplement:

For virus neutralization:

a. C5a
b. C4b
c. C1
d. C3a

Which of the following does not belong?

Answer 14

a and d

Question 15

Effector functions of COmplement:

Cell lysis

a. C5b
b. C9
c. C7
d. C3a

Which of the following does not belong?

Answer 15

d

Question 16

Activating Sub.:

Mannose groups on microbial cell

a. Classical
b. Alternative (Properdin)
c. Lectin

Answer 16

c

Question 17

Activating Sub.:

Immune complexes (2 IgG / IgM)

a. Classical
b. Alternative (Properdin)
c. Lectin

Answer 17

a

Question 18

Activating Sub.:

LPS, fingal cell walls, yeast, viruses tumor cells

a. Classical
b. Alternative (Properdin)
c. Lectin

Answer 18

b

Question 19

Activating Sub.:

IgA

a. Classical
b. Alternative (Properdin)
c. Lectin

Answer 19

b

Question 20

In classical pathway, IgG requires more than 2 to be activated

T or F

Answer 20

T

Question 21

Recognition unit:

C1q, C1r, C1s

a. Classical
b. Alternative (Properdin)
c. Lectin

Answer 21

a

Question 22

Recognition unit:

MBP, MASP-1, MASP2

a. Classical
b. Alternative (Properdin)
c. Lectin

Answer 22

c

Question 23

Recognition unit:

C3, Factor B, Factor D

a. Classical
b. Alternative (Properdin)
c. Lectin

Answer 23

b

Question 24

C3 Convertase

C4b2a

a. Classical
b. Alternative (Properdin)
c. Lectin

Answer 24

a and c

Question 25

C3 Convertase

C3bBb

a. Classical
b. Alternative (Properdin)
c. Lectin

Answer 25

b

Question 26

C5 Convertase

C4b2a3b

a. Classical
b. Alternative (Properdin)
c. Lectin

Answer 26

a and c

Question 27

C5 Convertase

C3bBb3b

a. Classical
b. Alternative (Properdin)
c. Lectin

Answer 27

b

Question 28

MAC:

C5b6789

a. Classical
b. Alternative (Properdin)
c. Lectin

Answer 28

All of the above

Question 29

C3bBb

a. C3 Convertase
b. C5 convertase

Answer 29

a

Question 30

C4b2b

a. C3 Convertase
b. C5 convertase

Answer 30

a

Question 31

C3bBb3b

a. C3 Convertase
b. C5 convertase

Answer 31

b

Question 32

C4b2b3b

a. C3 Convertase
b. C5 convertase

Answer 32

b

Question 33

What is the end result of all pathways?

Answer 33

Cell lysis