15.2 Types of Graft Rejection Flashcards
This type of graft rejection usually happens minutes to hours and preformed antibodies to ABO, HLA, and certain antigens bind to donor vascular endothelium, activating complement and clotting factors
Hyperacute
This type of graft rejection may lead to thrombus formation, ischemia, and necrosis of transplanted tissue
Hyperacute
This type of graft rejection usually happens days and is similar to hyperacute
accelerated
This type of graft rejection usually happens for days to months where cell-mediated response to foreign MHC-expressing cells.
Acute
In acute graft rejection: ___________ produces cytokines and induce delayed-type hypersensitivity
CD 4+ T cells
In acute graft rejection: ___________ Mediates cytotoxic reactions
CD8+ T cells
This type of graft rejection happens when antibodies produced against HLA antigens bind to vessel walls activate complement, and induce transmural necrosis and inflammation
Acute
This type of graft rejection usually happens 1 year or more, it is a delayed-type of hypersensitivity response and possibly antibodies to foreign HLA antigens on the Graft.
Chronic
This type of graft rejection can cause graft arteriosclerosis and smooth muscle proliferation to occur, resulting in fibrosis, scarring, and narrowing of vessel lumen
Chronic
This type of graft rejection usually happens for 100 days or more where T cells in HSC, lung or liver transplants reac against foreign HLA prteins i the recipient cells causing massive cytokine release, inflammation, and tissue destruction in various locations throughout the body
Graft versus host disease
Timing of hyperacute after transplant?
Minutes to hours
Timing of Chronic after transplant?
1 year or more
Timing of Acute after transplant?
Days to months
Timing of Accelerated after transplant?
days
How to minimize Graft versus host disease?
Radiation
