13.1 Antibodies and TCR Flashcards
Antibodies have Low molecular weight
T or F
F
High
Glycoprotein proteins secreted by _______ in response to an antigenic stimulation
Plasma cells
Functions of Ab:
Combine with Antigen on cellular surfaces
T or F
T
Functions of Ab:
Cannot neutralize toxin substances even by binding to it
T or F
F
Can
Functions of Ab:
Can facilitate phagocytosis and opsonin
T or F
T
Basic functional unit of Ab?
Monomer
how many binding site for a monomer?
2
Basic Structural unit of IgG
Monomer
Monomer has tetrapeptide meaning
__ Heavy chain
__ Light chain
2
2
What region of Antibody is the most flexible part?
Hinge region
What chain can hold the antibody together in general?
Disulfide bond
Disulfide bond:
Holds Fc and Fab together
a. Interchain
b. Intrachain
a
Disulfide bond:
Holds Fab together
a. Interchain
b. Intrachain
b
Globular regions of polypeptide chain which stabilized the intrachain disulfide bonds
Domains
___________ residue which increases the solubility of the antibody
Carbohydrates
Domains on the Variable Regions include VH and VL collectively termed as?
Fab
Domains on the constant regions include CL, CH1, CH2 and CH3:
CH1: Bind to ______
CH2: Binding site for C1_
CH3: Attachment to P______________
Fc: Compose of Ch2 and Ch3
C4b
q
Phagocyte
Hypervariable Regions are _____ loops
Disecrete
Hypervariable regions are found in?
Fab
Complementarity-determining regions is the exact or specific areas where the _______ bind
epitopes
The area where the epitopes bind is in the CDR and these CDR are found in the?
Fab region
Sequence of amino acid comprising polypeptide chain changes
a. Variable region
b. Constant region
a
Sequence of amino acid comprising polypeptide chain is fixed and unchanging
a. Variable region
b. Constant region
b
Carboxyl group on its terminal end
a. Variable region
b. Constant region
b
Amino group (NH2 on its terminal end
a. Variable region
b. Constant region
a
Function: binding site for Antigen
a. Variable region
b. Constant region
a
Related to the biologic activieites of Ig Molecule
a. Variable region
b. Constant region
b
