2.2 Natural / Innate / Native Immunity Flashcards
Intact skin, mucus membrane coated with mucins and ciliated cells
a. External Defense mechanism
b. Internal Defense mechanism
a
Ciliated cells do sweeping action to prevent pathogen entering
T or F
T
Acidity of the stomach
a. External Defense mechanism
b. Internal Defense mechanism
a
Lysozymes inhibits gram (+) bacteria
a. External Defense mechanism
b. Internal Defense mechanism
a
Lactic acids in sweat
a. External Defense mechanism
b. Internal Defense mechanism
a
Normal Flora
a. External Defense mechanism
b. Internal Defense mechanism
a
1st Line of defense
a. External Defense mechanism
b. Internal Defense mechanism
a
2nd line of defense
a. External Defense mechanism
b. Internal Defense mechanism
b
Cellular and humoral components
a. External Defense mechanism
b. Internal Defense mechanism
b
Phagocytic that are known to be frustrated phagocytosis
neutrophils
1st innate cells that go to the site
Neutrophils
Neutrophils has a long life span
T or F
F
Short
Phagocytic that undergo sustained phagocytosis
Monocytes
Macrophage:
What organ has Kupffer cells
liver
Macrophage:
What organ has Alveolar
lungs
Macrophage:
What organ has Microglia
CNS
Macrophage:
What organ has Osteoclast
Bone
Macrophage:
What organ has Langerhans
Skin
Macrophage:
What organ has Histiocytes
CT
Macrophage:
What organ has Littoral cells
Spleen
Macrophage:
What organ has Mesangial
Kidney
Macrophage produces a chemical signal that are involve signaling of other cells
Cytokines
Example of Cytokines
IL1, IL2, IFN
Macrophage can repair, and clean
T or F
T
Macrophage can be adaptive immune response
T or F
T
Macrophage can be an antigen presentation which is why it can be both innate and adaptive
T or F
T
Both Neutrophils and Monocytes/Macrophage posses Fc Receptors, and CRP reaction
T or F
T
Both Neutrophils and Monocytes/Macrophage posses PRRs which is a ____ like receptors
Toll
WBC that mediates inflammation
Basophils
WBC that mediates Parasite and allegic reaction
Eosinphils
This cells is similar function to basophils but no the same
Mast cells
WBC that develop in the BM which can be seen in the spleen, liver that share some properties with T Cells
NK cells
WBC that is antiviral, anti tumor, and killing via granzymes, and perforins
NK cells
Also known as Antibody Dependent Cell Mediated Cytoxicity
NK cells
NK cells can cause Indirect killing
T or F
F
Direct
Major (Professional) Antigen presenting cells
Dendritic cells
Dendritic cells contains many MHC _ which possess only on antigen presenting cells
2
Secretion substances (Humoral) contains antiviral properties, example are C___________, L_________, I_________
Complement
Lysozymes
Interferons
Pattern Recognition Receptors are present in Acquired immune cells (Monocytes / Macrophage)
T or F
F
Innate
Pattern Recognition Receptors
recognizes molecular patters that are foreign to the IS such as P____, D_____
PAMPs, DAMPs
Toll Like Receptor:
________ - Peptidoglycan (GR__)
TLR2
+
Toll Like Receptor:
________ - LPS (Endotoxin)
TLR4
Toll Like Receptor:
________ - Lipopeptides of Mycobacteria
TLR1
Toll Like Receptor:
________ - dsRNA
TLR3
Toll Like Receptor:
________ - ssRNA
TLR7 and 8
Toll Like Receptor:
________ - dsDNA
TLR9
