11.2 Factors affecting immunogenecity Flashcards
What are the factors affecting immunogenecity?
Foreignness
Size
chemical Composition complexity
Route, Dosage, and Timing
Adjuvants
The More foreign, the more immunogenic
T or F
T
Type of Foreigness
Antigen for Self
Autoantigen
Type of Foreignness
Antigen coming from same species but different indiv
Alloantigens
Type of Foreignness
Antigen comes from different species
Heteroantigens
Hetero Ags exist in unrelated plants or animals but are either identical or closely-related in structure so that ab to one can cross-react with antigen of the other
Heterophile antigens
Size:
How many daltons for Good immunogen? atleast?
10,000 daltons
Size:
How many daltons for EXCELLENT immunogen? atleast?
> 100,000
In chemical composition and complexity:
The more complex, the less immunogenic
T or F
F
More immunogenic
Route, dosage, and timing:
Which is more effective?
a. Subcutaneously
b. Intravenously
c. Orally administered
d. Intranasal Route
b
When it comes to complexity of antigens, which is more complex proteins or lipid?
Proteins
Substances administered with an immunogen that increases and hastens the immune response
Adjuvants
FDA approved adjuvant?
Alum adjuvant
Freund’s Adjuvant contains the solution of what bacteria?
Mycobacteria
