2.6 Flashcards
what type of cell involved in cell-mediated immunity produces cytokines and activate and recruit other cells
CD4 helper T cells
what type of cell involved in cell-mediated immunity kills infected cells
CD8 cytotoxic T cells
TCRs expressed on T cell clones can only recognize ___
one peptide / MHC complex
T/F several peptides can be presented by different MHC I and MHC II molecules on the surface of the same DC
true
what patrols LN in search of antigens with the perfect fit
T cells
what does Th1 make and activate
- IFN gamma
- macrophages
what does Th2 make and activate
- IL4, IL5, & IL13
- eosinophils
what does Th17 make and activate
- IL17 & IL22
- neutrophils
what determines the fate of naive T cells
cytokines produced by DC or other innate cells
what is involved in the activation of macrophages by Th1 cells
CD40-CD40L & IFN gamma - IFN gammaR
what do macrophages produce & upregulate
- cytokines
- MHC, costimulatory molecules, & microbicidal activities
what induces B cells to produce IgE
IL-4
what induces eosinophil activation and mediates worm elimination
IL-5
what induces monocytes to become M2 macrophages and peristalsis of the gut
- IL-4 & IL-13
what are M1 macrophages involved in
killing & inflammation
what are M2 macrophages involved in
tissue repair and inhibition of inflammation
what produces IL-17 & IL-22
Th17
what induces antimicrobial peptide production by epithelial cells
IL-17 & IL-22
what mediates recruitment of neutrophils via induction of cytokines / chemokines production from other cells
IL-17
what mediates production of Ig by B cells
IL-21
what is important for extracellular microbes
Th17
what are released from granules and mediate killing
- perforin
- granzyme
what cells activate macrophages to lyse intravesicular microbes
Th1
what kills infected cells with help from Th1 cells
CD8
which statement concerning Thelper cells is correct?
a - Th1 cells make IL-4 and promote neutrophil activation
b - Th1 cells make IL-17 and induce macrophage activation
c - Th1 cells make IFN gamma and mediate eradication of intracellular bacteria
d - Th2 cells make IL-4 mediate eradication of extracellular bacteria
e - Th2 cells make IL-5 and inhibit worm killing by eosinophils
c - Th1 cells make IFN gamma and mediate eradication of intracellular bacteria
what is the function of Th17 cells in response to infection?
a - Th17 cells kill cells infected with intracellular microbes
b - Th17 cells trigger antimicrobial peptides for clearance of intracellular bacteria
c - Th17 cells help recruit neutrophils to the mucosa for clearance of extracellular microbes
d - Th17 cells lead to mast cell degranulation for clearance of fungus
e - Th17 cells make IL-5 and trigger worm killing by eosinophils
c - Th17 cells help recruit neutrophils to the mucosa for clearance of extracellular microbes
how do activated cytotoxic T cells (CTL) kill cells infected with an intracellular microbe?
a - CTL are activated with help from macrophage to generate MAC which lyse infected cells
b - CTL are activated by DC and receive help from Thelper cells to produce perforin and granzyme which lyse infected cells
c - CTL are activated by DC and Th1 cells to produce ROS which induce apoptosis of the infected cells
d - CTL are only activated by B cells to produce perforin and granzyme that lyse infected cells
e - CTL produce nitric oxide that kill infected cells
b - CTL are activated by DC and receive help from Thelper cells to produce perforin and granzyme which lyse infected cells
match the following terms:
1 - Th17
2 - Th2
3 - Th1
a - IL-4
b - IFN gamma
c - IL-17
1 - c
2 - a
3 - b
cytokines produced by DC and other innate cells determine the date of naive T cells and the cytokine they will produce. What cytokines accurately induce Th cell differentiation?
a - IFN gamma induces Th2
b - IL-12 induces Th17
c - IL-6 induces Th1
d - IL-5 induceTh17
e - IL-4 induces Th2
e - IL-4 induces Th2
