Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Microbiology & Immunology > 2.4 > Flashcards

2.4 Flashcards

You may prefer our related Brainscape-certified flashcards:
Biology 101 flashcards
1
Q

how are T cells in lymphoid organs alerted when there is an infection

A

APC are captured and processed and the antigens are transported to T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

antigens are transported from ___ to ___ where recognition by __ occurs

A
  • tissue / mucosa
  • lymphoid organs
  • T cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what resides in tissues and captures microbes and antigens

A

dendritic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

___ are drained via lymphatic vessels or enter blood stream

A

cell-free antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

the majority of DC in tissues and lymphoid organs are ___

A

classical DC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

classical DC are in the ___

A

t cell zone of lymph nodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

___ capture and process protein antigens

A

immature dendritic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

DC are activated via ___ and migrate to lymph nodes via ___

A
  • PRR
  • chemokine gradient
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

chemokine gradient is produced by the upregulation of ___ and ___

A
  • chemokine receptors (CCR7)
  • costimulatory molecules
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

___ present protein antigens to T cells

A

mature DC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what determine the specific recognition of antigens by T cells

A

major histocompatability complex (MHC) molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MHC molecules display ___ derived from ___

A
  • peptides
  • protein antigens
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

___ on T cells recognize ____ displayed by ___ on APC

A
  • T cell receptors
  • peptide antigens
  • MHC molecules
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what are human MHC proteins called

A

human leukocyte antigens (HLA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what are the 2 sets of highly polymorphic genes

A
  • Class I MHC genes
  • Class II MHC genes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

___ & ___ are susceptibility factors for periodontitis

A
  • HLA-A9
  • HLA-B15
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what is the structure of MHC class I molecules

A
  • membrane proteins containing a peptide-binding cleft at the amino-terminal
  • alpha chain associated with beta 2 - microglobulin with a groove accomodating 8-9 aa peptide
18
Q

what is the structure of MHC class II molecules

A
  • membrane proteins containing a peptide-binding cleft at the amino terminal
  • alpha & beta chains with a groove accomodating 10-30 aa peptide
19
Q

CD8 T cells only recognize peptides presented by ___

A

MHC class I

20
Q

how are peptides recognized by CD8 Tcells

A

the alpha 3 binds CD8 on CD8 Tcells

21
Q

CD4 T cells only recognize peptides presented by ___

A

MHC class II

22
Q

how are peptides recognized by CD4 T cells

A

beta 2 binds CD4 on CD4 T cells

23
Q

what do MHC polymorphisms ensure

A

that a population can deal with microbe diversity

24
Q

what are MHC class II expressed on & induced by

A
  • APC
  • IFN gamma
25
Q

what are MHC class I expressed on

A

all nucleated cells

26
Q

MHC molecules only bind ___

A

peptides derived from protein antigens

27
Q

T/F one APC can display multiple peptides

A

true

28
Q

how are proteins converted into peptides?

A

antigen processing pathways

29
Q

what are the 3 steps of extracellular protein processing

A

1 - antigen internalization
2 - antigen degradation in lysosome
3 - antigen (peptide) association with Class II molecules in endosome

30
Q

extracellular proteins are processed in ___ & peptides are displayed on ___ to ___

A
  • endosome / lysosome
  • MHC class II
  • CD4 cells
31
Q

cytosolic proteins are processed by ___ & peptides are displayed on ___ to ___

A
  • proteasome & endoplasmic reticulum
  • MHC class I
  • CD8 cells
32
Q

what are the 3 steps of cytosolic protein processing

A

1 - antigen degradation by proteasome
2 - peptide transport via TAP in ER
3 - antigen (peptide) association with class I molecules

33
Q

what is the significance of MHC-associated antigen presentation

A

optimization of response to different microbes in different locations

34
Q

extracellular microbes are associated with __

A

CD4 T cells

35
Q

intracellular microbes are associated with ___

A

CD8 T cells

36
Q

MHC molecules only bind ___

A

protein antigens

37
Q

MHC I molecules are composed of ___ & ___ and bind to __

A
  • alpha chain
  • beta-microglobulin
  • CD8
38
Q

MHC II molecules are composed of ___ & ___ and bind to

A
  • alpha chain
  • beta chain
  • CD4
39
Q

how are extracellular proteins processed for presentation to T cells?

a - processed in the endosome/lysosome and loaded onto MHC class II for presentation to CD4 T cells
b - processed in the endoplasmic reticulum and loaded onto MHC class II for presentation to CD8 T cells
c - processed in the endoplasmic reticulum and loaded onto MHC class I for presentation to CD4 T cells
d - processed in the endosome and loaded onto MHC class II for presentation to CD8 T cells

A

a - processed in the endosome/lysosome and loaded onto MHC class II for presentation to CD4 T cells

40
Q

what statement concerning antigen processing and presentation is correct?

a - class II molecules are composed of one beta2-microglobulin and one alpha chain
b - CD8 T cells recognize peptides associated with MHC class II
c - MHC locus consists of two sets of non-polymorphic genes
d - peptides bind outside of the cleft of MHC class I & II molecules
e - CD8 T cells recognize peptides associated with MHC class I

A

e - CD8 T cells recognize peptides associated with MHC class I

41
Q

what statement below reflects accurately antigen presentation to T cells?

a - neutrophils present antigen bound to TLR to T cells
b - B cells present antigen bound to BCR to T cells
c - macrophages present antigen bound to scavenging receptor to T cells
d - DC present antigen bound to MHC molecules to T cells
e - DC present antigen bound to microglobulin to T cells

A

d - DC present antigen bound to MHC molecules to T cells

Microbiology & Immunology (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions