1.83 Stress 1 Flashcards

1
Q

What is stress

A

Stress describes pathophysiological changes following exposure to diverse physical/ chemical or emotional challenges
• Encompasses:
i. the input (stress stimuli)
ii. the processing systems (i.e. areas of the brain)
the output (stress response)

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2
Q

what is the behavioural response to stress?

A

○ Fear
○ Anxiety
○ Alertness (changes in sleep pattern)
○ Changes in cognition (learning and memory)
Stereotyped behaviour - displacement / coping - playing with hair etc.

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3
Q

What is the autonomic response to stress? (sympathetic nervous system)

A

○ Cardiovascular /respiratory
○ Gastrointestinal
Metabolic and thermoregulatory

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4
Q

What is the Hypothalamo-Pituitary-Adrenal (HPA) response to stress?

A

Metabolic

Immunological

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5
Q

What is the first sub-division of stimulus of stress and what does it involve?

A

Psychological - Uncontrolled stress
External - bereavement
Internal - perfectionism
- controlled - self made/wanted
-acute
-chronic

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6
Q

Three stages of Selye’s General Adaptation Syndrome…

A
  1. Acute Stress Alarm Reaction “Fight or Flight”
  2. Episodic Stress Resistance Struggle to overcome
  3. Chronic Stress Exhaustion Fatigue, irritability, vulnerable to illness
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7
Q

In acute stress what happens when the stressful situation ends?

A

When the stressful situation ends, endocrine signals switch off the stress response and the body returns to normal

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8
Q

What are the common features of acute stress?

A
○ Tachycardia and hypertension 
		○ Increased metabolic rate 
		○ Reduced gastrointestinal activity 
		○ Increased alertness 
Increased levels of adrenaline and adrenal steroids
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9
Q

What is episodic stress?

A

Extended over-arousal due to repeated acute stress

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10
Q

How can episodic stress present?

A

○ tendency to be abrupt and irritability may appear as hostility, leading to deterioration in interpersonal relationships
○ persistent tension headaches and migraine
○ common to be short-tempered, irritable, anxious and tense
○ workplace becomes a very stressful environment
combination of sleeplessness and tiredness

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11
Q

What is chronic stress?

A

• Occurs when an individual fails to see way out of threatening or miserable situation
• Arises from unrelenting demands and pressures for long periods
Many chronic stresses relate to relationships and position in society

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12
Q

How can early childhood experiences change psychological and biological responses?

A

May stem from traumatic, early childhood experiences - psychological; experiences make you percieve the world as more stressful - physical; HPA axis sensitivity reset

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13
Q

What are the symptoms of chronic stress?

A
• Emotional distress 
   □ combination of anxiety, depression and anger/irritability - the three stress emotions 
• Muscular problems
   □ especially generalised muscle pain and tension headache
• Stomach, gut and bowel problems 
   □ e.g. gastric ulceration, IBD
• Constant tiredness
Increased risk of coronary heart disease
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14
Q

Which type of stress affects the emotions and which affects the mood?

A

Acute stress - emotion - fear and anger

Chronic stress - mood - depression and grief

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15
Q

What is anxiety?

A
  • A type of stress closely related to fear and involves similar neural circuitry
  • It is the physical and psychological response to a perceived threat (as opposed to a real threat which triggers an acute stress response)
  • The threat can be physical, social or emotional and may be triggered by a prior experience
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16
Q

Which two brain areas are responsible for mood?

A

the amygdala, which generates fear in response to danger

the hippocampus, which plays an important part in memory formation as well as in mood and motivation

17
Q

Which part of the brain is responsible for thought?

A

Prefrontal cortex

18
Q

What can the removal hippocampus and amygdala result in, (bilateral medial temporal lobectomy)?

A

Epilepsy

19
Q

Where and what is the name of the principle site of noradrenaline synthesis?

A

Locus coerulus in the brainstem

20
Q

What is CRH?

A

• Corticotrophin releasing hormone (CRH) is secreted by the hypothalamus during a stress response
• It is the main regulator of the HPA axis
plays a major role in our physiological adaptations to acute and chronic stress

21
Q

Where CRH neutrons found?

A

• CRH neurones are found in many of the areas of the brain associated with stress
• Locus coeruleus
• Paraventricular nucleus of the hypothalamus (PVN)
Central nucleus of the amygdala

22
Q

Where do CRH releasing neurons project onto?

A

Hippocampus

Amygdala

23
Q

Explain activation of CRH and noradrenaline?

A

Look at PWP