Yang (8 questions) Flashcards
Contrast the organization and neuron types in the ANS (cholinergic vs adrenergic, pre vs post ganglionic)
Identify the major neurotransmitters found in the ANS
Differentiate sympathetic control of the sweat glands, kidney, and adrenal glands from other areas of the sympathetic nervous system
Use interchangeably the terms describing drugs affecting the ANS (cholinergic vs parasympathomimetic)
Autonomic Nervous System
-regulation of involuntary muscle, glands
-autonomic tone (active at rest)
-sympathetic and parasympathetic
ANS neuron path
-preganglionic (CNS) projects to postganglionic neuron (peripheral)
-projects to target organ
Acetylcholine is a transmitter for:
-all PREganglionic neurons
-POSTganglionic in PARAsympathetic NS
-also SWEAT glands
Norepinephrine is a transmitter for:
-most SNS POSTganglionic neurons
other neurotransmitters
-epinephrine: adrenal medulla
-dopamine: renal vasc
PSNS neuron pathway
- LONG PREganglionic
-release ACh - SHORT POSTganglionic
-release ACh to target
SNS neuron pathway
- SHORT PREganglionic neurons
-release ACh - LONG POSTganglionic
-release NOREPINEPHRINE to target organ
*** think of the S in SNS standing for Short
Sweat glands
-stress sweat: norepinephrine
-thermoregulation: ACh
Adrenal Gland
-PREganglionic neurons synapse directly on gland
-release EPINEPHRINE into circulation
Kidneys
-DOPAMINE
Most POSTganglionic sympathetic neurons release what?
-norepinephrine
PSNS agonists are also called
-cholinergic
-muscarinic agonist
SNS agonists are also called
-Adrenergic (agonist)
Cholinergic receptor subtypes
-Nictotinic
-Muscarinic
Muscarinic receptors
-cholinergic
-GPCRs
-M1, M3, M5 (Gq)
-M2, M4 (Gi)
Adrenergic receptors
-a1 (Gq)
-a2 (Gi)
-B1,2,3 (Gs)
**Gq Gi Gs = qis (kiss)
a1
-vasoCONSTRICT
-Gq
-located on smooth muscle tissues
a2
-DECREASES neurotransmitter release
=INHIBIT SNS output
-Gi
B1, B2, B3 receptors
-Gs
ANS functions
-regulate BP
-HR
-bronchoconstriction/dilation
