Exam 1 Indirect Adrenergic drugs Flashcards
Indirect adrenergic agonist mechs
-reverse action of NET and DAT
-MAOi
-NET blockers
NET and DAT reversers
-Amphetamine
-Pseudoephidrine
Indirect adrenergic agonists
-Amphetamine
-Ephedrine (not really)
-pseudoephedrine
-Phenelzine
-selegiline
-cocaine
-methylphenidate
-atomexetine
Amphetamine mech
-NET and DAT reversal
-indirect adrenergic
Amphetamine structure
monoamine with methyl on C
amphetamine use
-narcolepsy
-ADHD
-appetite suppressant
Amphetamine problems
-anorexia
-poor growth
-insomnia
-jitteriness
-inc HR, BP, stroke, arrhytmias, death
-agitation, confusion, addiction
(-) ephedrine
-R config
-direct adrenergic activity
(-) ephedrine problems
-incr BP
-stroke
-death
-banned from weigh loss supplements
(+) Pseudoephedrine mech
-NET reversal
Pseudoephedrine use
-nasal congestion
MAOi drugs
-phenelzine
-selegiline
Wine and Cheese effect
-Tyramine in wine, beer, cheese
-MAOi decreases metabolism of tyramine
-huge release of NE
=HTN CRISIS!
NET blockers
-cocaine
-methylphenidate
-atomexetine
Cocaine mech
-indirect adrenergic
-block NET and DAT
-decrease uptake
-keep NE in cleft
=inc signaling
Cocaine use
-local anesthetic
-nasal mucosa
-vasoCONSTRICTION
Cocaine problems
-inc BP and HR
-potential for stroke, MI, death
-euphoria, alertness, addiction
Methylphenidate mech
-indirect adrenergic
-block NET and DAT
-enhance NE signaling
methylphenidate use
-ADHD
-narcolepsy
methylphenidate problems
-similar to amphetamine
-priapism
-addictive
Atomexetine mech
-selective NET inhibitor
Atomexetine use
-ADHD
Atomextine problems
-suicide
-priapism
-not as good
