Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Therapeutics > Rosacea + Psoriasis > Flashcards

Rosacea + Psoriasis Flashcards

1
Q

types of rosacea

A

-telangiectatic
-papulopustular
-phytmatous
-ocular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Rosacea

A

-inflammatory dermatosis
-vascular instability
-central part of face
-flushing/blushing
-erythema, papules, pustules
-telangiectasia
-fair complexioned women

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

telangiectatic rosacea

A

-visibly dilated blood cells
-very red skinp

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

papulopustular rosacea

A

-resembles acne
-“adult acne”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Phytmatous rosacea

A

-enlarged sebaceous glands esp in nose
-more common in men

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Ocular rosacea

A

-watery, bloodshot eyes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Rosacea triggers

A

-TEMP
-food
-med conditions
-emotions
-exertion
-skin products
-drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Drugs that cause rosacea

A

-vasodilators
-TCS
-nicotinic acid
-ACE inhibitors
-Ca channel blockers
-statins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Nonpharma tx of rosacea

A

-avoid triggers and sun
-use mild soap
-adhere to topical meds
-allow 5-10 min penetration before applying makeup

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

mild rosacea tx

A

-avoid triggers
-topical abx
-retinoids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

mod rosacea tx

A

-oral abx
-retinoids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

severe rosacea tx

A

-oral isotrentinoin
-laser tx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Topical abx for rosacea

A

-Metreonidazole 1% cream, gel, lotion
-apply BID
-Clindamycin
-Sulfacetamide and sulfur

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Topical retinoids for rosacea

A

-azelaic acid 15% gel
-antibac, comedolytic, anti inflam
-less acidic = better absorbed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

New tx for rosacea

A

-Brimodine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Brimonidine (mirvasco)

A

-0.33% gel
-a-2 agonist
-tx persistent erythema
-opthalmic drops for ocular rosacea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Oral abx for rosacea

A

-doxy or minocycline 50-100 mg qd or BID
-mod to severe
-alone or combo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Laser therapy for rosacea

A

-remove blood vessels
-reduce redness
-minimum 3 treatments
-SEVERE tx

19
Q

Psoriasis

A

-chronic autoimmune inflammatory skin disorder
-T-lymphocyte mediated disease
-keratinocyte proliferation
-thick, red patches covered by silver scales
-7x faster skin growth
-onset around age 40
-series of exacerbations/remissions

20
Q

Psoriasis common sites

A

-scalp
-face
-pit
-elbows and knees
-butt
-trunk
-groin

21
Q

Types of psoriasis

A

-plaque
-scalp
-psoriatic

22
Q

Psoriasis classification

A

-limited <5% BSA
-mod 5-10% BSA
-severe >10% BSA

23
Q

Psoriasis triggers

A

-stress
-cold
-injury/infection
-smoking
-drugs (nsaids, ace, lithium)
-diet

24
Q

Goals of psoriasis tx

A

-dec symptoms
-dec BSA
-improve QOL
-reduce inflammation
-clear lesions
-prolong periods between exacerbations

25
Q

Psoriasis non pharma tx

A

-sun
-baths
-emollients
-keratolytics (salicylic acid 2%)

26
Q

Approach to psoriasis tx

A
  1. topical
  2. UV
  3. Systemic
  4. Biologic
27
Q

Topical tx of psoriasis

A

-most effective for <20% BSA
-most pt succeed

28
Q

Topical options for psoriasis

A

-emmolients (use for all pt)
-TCS
-Calipotreine/Calcitriol
-TCS + Vit D
-TCS + Tazarotene
-calcineurin inhibitor

29
Q

TCS for psoriasis

A

-sec scaling, redness, itching
-economical
-shampoo version for scalp
-high potency ointment better for scaly lesions
-risk of tachyphylaxis

30
Q

Tachyphylaxis

A

-tolerance to anti-inflammatory activity of TCS w repeated use
-may alternate w other topical meds to avoid

31
Q

Occlusion of TCS

A

-enhances pentration
-plastic wrap + t-shirt
-leave on 6 hours
-10x penetration

32
Q

High/Very-high potency TCS for psoriasis

A

-SEVERE lesions and thick skin where max penetration is needed
-do NOT use on face
-dont use more than 2 weeks
-no more than 50g/week
-switch to mid-potency after control

33
Q

Phototherapy for psoriasis

A

-mild-mod that failed topical tx
-combo w systemic/biologics for SEVERE tx
-role in maintenance tx

34
Q

phototherapy mech

A

-immunomodulatory effect
-UVA penetrates better (thick lesions)
-NB-UVB is tx of choice (thinner lesions)

35
Q

NB-UVB

A

-first line
-thinner lesions
-20-25 txs 2-3x a week
-cost effective but inconvenient

36
Q

Phototherapy risks

A

-UVA more than UVB
-skin aging and cancer
-PUVA?
-Methoxsalen to prevent risks

37
Q

SEVERE psoriasis tx

A
  1. biologic therapy
  2. Systemic therapy
37
Q

Methoxsalen

A

-photosensitizer
-0.6-0.8mg/kg PO 2 hours before UVA tx
-2-3 tx/week

38
Q

Biologic tx for severe psoriasis

A

-tumor necrosis factor inhibitors
-T-cell activation inhibitors

39
Q

Systemic tx for severe psoriasis

A

-try biologics first
-oral retinoids
-cyclosporine
-methotrexate

40
Q

Cyclosporine

A

-calcineurin inhibitor
-qd
-monitor renal, BP, drug concentration, preg cat C
-HTN, nephrotoxicityy, tremors, HA, risk of infections

41
Q

Methotrexate

A

-immunosuppressant
-monitor CBC, LFTs, renal function, preg category X
-liver bx after 3.5-4g total dose
-inc risk of infections
-once weekly
-most cost effective
-nauea, anorexia, fatigue, stomatitis, BM suppression, hepatotoxicity, photosensitivity, pneumonitis

42
Q

Key aspects of biologics tx

A

-v expensive
-prior authorization
-for pt that failed other therapies
-well tolerated
-injection site discomfort
-monitor infections/bleeding
-supp w topical
-do NOT admin live virus vax

43
Q

After controlling psoriasis w systemic therapy

A

-use emollients
-go back to topical
-some use continuous tx

Therapeutics (78 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions