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Therapeutics > Final Drugs > Flashcards

Final Drugs Flashcards

1
Q

Glaucoma

A

-Pilocarpine (M3)
-Brimonidine (a2)
-Timolol

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1
Q

Pilocarpine

A

-M3
-inc secretions
-tx glaucoma and cotton mouth

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2
Q

Bethanechol

A

-cholinergic
-GI stim
-urinary RETENTION

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3
Q

Methacholine

A

-cholinergic
-test hyperactive airways

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4
Q

Carbachol

A

-ocular
-cholinergic
-glaucoma

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5
Q

Cholinergic side effects

A

-Diarrhea
-Urination
-Miosis
-Bradycardia
-BronchoCONSTRICTION
-Emesis
-Lacrimation
-Salivation + Sweating

-DUMBBELS
-inc secretions

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6
Q

Pralidoxime

A

-AChE inhibitor
-tx pesticide/nerve poisoning
-blah blah blash esteratic site
-combine w atropine
-tx before aging occurs!

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7
Q

Donepezil

A

-tx alzheimers

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8
Q

Rivastigmine

A

-AChE inhibitors
-lose effectiveness as alzheimer progresses

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9
Q

Galantamine

A

-AChE inhibitor
-alzheimers

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10
Q

Alzheimers

A

-Donepezil
-Rivastigmine
-Galantamine
-Memantine

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11
Q

Contraindications to PSNS

A

-asthma/COPD
-coronary deficiency
-peptic ulcer (inc acid secretion)
-obstruction of urinary/GI tract
-epilepsy

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12
Q

Atropine

A

-M ANTAgonist
-nonselective
-sympathetic activity
-tx motion sickness

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13
Q

Scopolamine

A

-more CNS action than atropine
-more drowsy
-tx motion sickness

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14
Q

Homatropine and Tropicamide

A

-antimuscarinic
-used optically bc short duration of action

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15
Q

Benztropine

A

-antimuscarinic
-tx parkinsons
-sedative activity

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16
Q

Ipratropium

A

-antimuscarinic w receptor activity similar to atropine
-tx COPD, sometimes asthma

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17
Q

Glycopyrrolate

A

-pre-op to reduce secretions in GI
-antimuscarinic

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18
Q

Tolterodine (Detrol)

A

-M3 antimuscarinic
-tx overactive bladder

19
Q

Neuromuscular blocking drugs

A

-Tubocurarine (blocks)
-Succinylcholine (activates then blocks)

20
Q

Tubocurarine

A

-nicotinic ANTAgonist
-neuromuscular blocker
-skeletal muscle relaxation

21
Q

Succinylcholine

A

-N agonist then causes depolarization
-muscle paralysis
-neuromusc blockade

22
Q

Botulinum toxin

A

-inhibit release of ACh
-tx muscle spasms, hyperhidrosis

23
Q

Hexamethonium

A
24
Q

Norepinephrine (NE)

A

-activates a and B1
-a1: vasoCONSTRICTION = inc BP
-B1: inc heart force and conduction

25
Q

Epinephrine

A

-a1: inc BP, inhibit insulin secretion
-B1: inc HR
-B2: vasodilation (dec BP) and bronchodilation, use glycogen

-tx anaphylaxis or cardiac arrest
-also counter HYPOglycemia (inc glucose)

26
Q

Dopamine (intropin)

A

-D1: inc blood flow to kidney
-B1: inc HR high dose
-a1: in BP high dose

-tx shock, heart failure, IV

27
Q

a1 agonist drugs

A

-Phenylephrine
-Oxymetazoline

-decongestants

28
Q

Isoproterenol

A

-non-selective B-agonist
-tx Asthma, COPD, bradycardia

29
Q

B2 agonists

A

-Terbutaline
-Metaproterenol
-Albuterol
-Salmeterol
-Ritodrine

-tx asthma, premature labor

30
Q

B1 agonists

A

-Dobutamine
-Dopamine

31
Q

Dobutamine

A

-B1, a1
-acute heart failure and stress test

32
Q

Mirabegron

A

-B3
-tx overactive bladder

33
Q

a2 agonists

A

-Clonidine
-Methyldopa. (prodrug preg)
-Gunabenz
-Guanfacine
-Brimonidine
-Apraclonidine
-Tizanidine

-tx glaucoma, pain, HTN

34
Q

indirect sympathomimetics

A

-amphetamine
-pseudoephedrinne
-ephedrine
-tyramine

-dont take w MAO inhibitor
-promote NE release
-tx ADHD, narcolepsy, weight

35
Q

MAO inhibitors

A

-Phenelzine
-Selegiline

-do NOT coadmin w drugs that can cause HTN crisis
=inc NE

36
Q

NET inhibitors

A

-Cocaine
-Methylphenidate
-venlafaxine

37
Q

Cocaine

A

-block NET and DAT
=more NE
-local anesthetic

38
Q

Methylphenidate (ritalin)

A

-block NET and DAT
-tx ADHD, narcolepsy in children

39
Q

Atomoxetine

A

-NET inhibitor
-tx ADHD
-non-stimulant

40
Q

nonselective a antagonist

A

-Phenoxybenzamine
-Phentolamine
-tx HTN crisis but too many a2 effects (HYPOtension)

41
Q

a1 antagonists

A

-Prazosin
-Terazosin
-Doxazosin

-tx HTN and BPH

42
Q

Phenoxybenzamine

A

-a1/a2 ANTAgonist

43
Q

Nonselective B ANTAgonists

A

-propranolol
-Nadolol
-Timolol
-Pindolol
-Cartelol

44
Q

B1 ANTAgonists

A

-metoprolol
-Bisoprolol
-Atenolol
-Emolol
-tx HTN and agina
-dont use in asthma, COPD, heart failure

45
Q

a1,B1 ANTAgonists

A

-Labetalol
-Carvedilol
-tx HTN, heart failure

46
Q

Drugs that reduce NE release

A

-Bretylium Tosylate
-Reserpine
-rarely used but tx HTN

Therapeutics (78 decks)

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