Final Drugs Flashcards

1
Q

Glaucoma

A

-Pilocarpine (M3)
-Brimonidine (a2)
-Timolol

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1
Q

Pilocarpine

A

-M3
-inc secretions
-tx glaucoma and cotton mouth

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2
Q

Bethanechol

A

-cholinergic
-GI stim
-urinary RETENTION

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3
Q

Methacholine

A

-cholinergic
-test hyperactive airways

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4
Q

Carbachol

A

-ocular
-cholinergic
-glaucoma

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5
Q

Cholinergic side effects

A

-Diarrhea
-Urination
-Miosis
-Bradycardia
-BronchoCONSTRICTION
-Emesis
-Lacrimation
-Salivation + Sweating

-DUMBBELS
-inc secretions

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6
Q

Pralidoxime

A

-AChE inhibitor
-tx pesticide/nerve poisoning
-blah blah blash esteratic site
-combine w atropine
-tx before aging occurs!

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7
Q

Donepezil

A

-tx alzheimers

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8
Q

Rivastigmine

A

-AChE inhibitors
-lose effectiveness as alzheimer progresses

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9
Q

Galantamine

A

-AChE inhibitor
-alzheimers

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10
Q

Alzheimers

A

-Donepezil
-Rivastigmine
-Galantamine
-Memantine

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11
Q

Contraindications to PSNS

A

-asthma/COPD
-coronary deficiency
-peptic ulcer (inc acid secretion)
-obstruction of urinary/GI tract
-epilepsy

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12
Q

Atropine

A

-M ANTAgonist
-nonselective
-sympathetic activity
-tx motion sickness

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13
Q

Scopolamine

A

-more CNS action than atropine
-more drowsy
-tx motion sickness

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14
Q

Homatropine and Tropicamide

A

-antimuscarinic
-used optically bc short duration of action

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15
Q

Benztropine

A

-antimuscarinic
-tx parkinsons
-sedative activity

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16
Q

Ipratropium

A

-antimuscarinic w receptor activity similar to atropine
-tx COPD, sometimes asthma

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17
Q

Glycopyrrolate

A

-pre-op to reduce secretions in GI
-antimuscarinic

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18
Q

Tolterodine (Detrol)

A

-M3 antimuscarinic
-tx overactive bladder

19
Q

Neuromuscular blocking drugs

A

-Tubocurarine (blocks)
-Succinylcholine (activates then blocks)

20
Q

Tubocurarine

A

-nicotinic ANTAgonist
-neuromuscular blocker
-skeletal muscle relaxation

21
Q

Succinylcholine

A

-N agonist then causes depolarization
-muscle paralysis
-neuromusc blockade

22
Q

Botulinum toxin

A

-inhibit release of ACh
-tx muscle spasms, hyperhidrosis

23
Q

Hexamethonium

24
Norepinephrine (NE)
-activates a and B1 -a1: vasoCONSTRICTION = inc BP -B1: inc heart force and conduction
25
Epinephrine
-a1: inc BP, inhibit insulin secretion -B1: inc HR -B2: vasodilation (dec BP) and bronchodilation, use glycogen -tx anaphylaxis or cardiac arrest -also counter HYPOglycemia (inc glucose)
26
Dopamine (intropin)
-D1: inc blood flow to kidney -B1: inc HR high dose -a1: in BP high dose -tx shock, heart failure, IV
27
a1 agonist drugs
-Phenylephrine -Oxymetazoline -decongestants
28
Isoproterenol
-non-selective B-agonist -tx Asthma, COPD, bradycardia
29
B2 agonists
-Terbutaline -Metaproterenol -Albuterol -Salmeterol -Ritodrine -tx asthma, premature labor
30
B1 agonists
-Dobutamine -Dopamine
31
Dobutamine
-B1, a1 -acute heart failure and stress test
32
Mirabegron
-B3 -tx overactive bladder
33
a2 agonists
-Clonidine -Methyldopa. (prodrug preg) -Gunabenz -Guanfacine -Brimonidine -Apraclonidine -Tizanidine -tx glaucoma, pain, HTN
34
indirect sympathomimetics
-amphetamine -pseudoephedrinne -ephedrine -tyramine -dont take w MAO inhibitor -promote NE release -tx ADHD, narcolepsy, weight
35
MAO inhibitors
-Phenelzine -Selegiline -do NOT coadmin w drugs that can cause HTN crisis =inc NE
36
NET inhibitors
-Cocaine -Methylphenidate -venlafaxine
37
Cocaine
-block NET and DAT =more NE -local anesthetic
38
Methylphenidate (ritalin)
-block NET and DAT -tx ADHD, narcolepsy in children
39
Atomoxetine
-NET inhibitor -tx ADHD -non-stimulant
40
nonselective a antagonist
-Phenoxybenzamine -Phentolamine -tx HTN crisis but too many a2 effects (HYPOtension)
41
a1 antagonists
-Prazosin -Terazosin -Doxazosin -tx HTN and BPH
42
Phenoxybenzamine
-a1/a2 ANTAgonist
43
Nonselective B ANTAgonists
-propranolol -Nadolol -Timolol -Pindolol -Cartelol
44
B1 ANTAgonists
-metoprolol -Bisoprolol -Atenolol -Emolol -tx HTN and agina -dont use in asthma, COPD, heart failure
45
a1,B1 ANTAgonists
-Labetalol -Carvedilol -tx HTN, heart failure
46
Drugs that reduce NE release
-Bretylium Tosylate -Reserpine -rarely used but tx HTN