Primary ANS receptors

Question 1

Cholinoreceptors

Answer 1

-acetylcholine receptors
-nicotinic or muscarinic

Question 2

Adrenoceptors

Answer 2

-norepinephrine and epinephrine receptors
-alpha or beta

Question 3

Primary ANS receptors

Answer 3

-cholinoreceptors
-adrenoreceptors

Question 4

Nicotinic Receptors

Answer 4

-5 subunits ionotropic Na+ ion channel
-ligand-gated
-activated by nicotine
-ganglionic, skeletal muscle, neuronal CNS

Question 5

Nicotinic receptor mech

Answer 5

-opening leads to depolarization of membrane
= opens Na+ channels to produce action potential

Question 6

Muscarinic receptors

Answer 6

-GPCR
-7 transmembrane domain
-M1-M5
-Gq pathway or G1 pathway

Question 7

Gq pathway

Answer 7

-IP3 mobilize intracellular Ca++
-DAG, activate Protein kinase C

Question 8

M1, M3, M5 signal via

Answer 8

Gq pathway

Question 9

Gi pathway

Answer 9

-inhibitory
-adenylyl cyclase to cAMP to protein kinase

Question 10

M2 and M4 signal via

Answer 10

Gi pathway

Question 11

Adrenergic receptors in ANS

Answer 11

-a1 (a1A, a1B, a1D)
-a2
-B (B1, B2, B3)

Question 12

a1 receptor signals via

Answer 12

-Gq pathway
-mediates vasoconstriction

Question 13

a1 receptor distribution

Answer 13

-smooth muscle
-heart
-liver

Question 14

a2 receptor signals via

Answer 14

-Gi pathway (inhibitory)
-inhibt adenylyl cyclase
-reduce cAMP-dependent protein kinase
-activate certain K+ channels

Question 15

a2 receptors

Answer 15

-found pre-synaptically
-autoreceptors to inhibit sympathetic output which decreases transmitter release

Question 16

B receptors signal via

Answer 16

-Gs
-activate adenylyl cyclase
-increase cAMP
=phosphorylation of ion channels and other protein

Question 17

M2 and M4 interactions

Answer 17

-counteract B1 receptors
-K+ channel opens that causes hyperpolarization

Question 18

ANS major regulator of

Answer 18

-blood pressure
-heart function
-bronchoconstriction/dilation

Question 19

ANS and pharmacology

Answer 19

-many drugs with anticholinergic effects (important for elderly)
-cholinergics in pesticides and chemical weapons

Question 20

Adrenergic response of heart

Answer 20

-rate and force of contraction INCREASE
-receptor B1>B2

Question 21

Cholinergic response of heart

Answer 21

-rate and force of contraction DECREASE
-receptor M2

Question 22

Adrenergic response of blood vessels

Answer 22

-arteries and veins vasoCONSTRICT
-skeletal muscle vasoDILATES

Question 23

artery adrenergic response

Answer 23

-a1
-vasoCONSTRICT

Question 24

vein adrenergic response

Answer 24

-a1,2
-vasoCONSTRICT

Question 25

skeletal muscle adrenergic reponse

Answer 25

-B2
-vasoDILATE

Question 26

Predominantly Sympathetic

Answer 26

-arterioles
-veins
-sweat glands

-no PSNS innervation

Question 27

Predominantly parasympathetic

Answer 27

-heart
-eyes: iris and ciliary
-GI tract
-bladder
-salivary

Question 28

SLIDE 44

Answer 28

SLIDE 44 v important