Final Drugs 10-19 Flashcards
17a-hydroxylase
-more MC not enough steroids
-enlargemnt of adrenal glands
-HTN
-ambiguous genitalia
-progesteron
21-hydroxylase deficiency
-
Aminoglutethimide
-inhibit aromatase and P450scc
-block steroid production in some tumors
Ketoconaxole
-antifungal at low concentration
-inhibits P450scc, 17-a hydroxylase, 11-B hydroxylase
-tx HYPERglucocorticoid states (Cushing’s)
Testosteron
-feedback inhibition
-5a reductase to make DHEA
-aromatase to make estradiol
-dec HDL levels
5a-reductase inhibitors (antiandrogens)
-finasteride
-dutasteride
-tx BPH, baldness
Steroid ANTAgonists
-Cyproterone acetate
-Spirinolactone
Non-steroidal inhibitors
-Flutamide
-Enzalutamide
-tx prostate cancer
Estrogen mods
-17B OH required
-17-a blocks metabolism
-160OH dec
-hydroxyl
Nonsteroidal estrogens
-diethylstilbestrol
-chlorotrianisene
-tx menopause and prostate cancer
Tamoxifen
-prodrug
-SERM (partial)
-tx breast cancer
-inc thrombo
-prevent osteoporosis
Toremifene and Ospemifene
-SERMs
-tx breast cancer
-tx dyspareunia
Raloxifene
-SERM
-prevent osteoporosis
-dec LDL
-inc risk of clots
-dec risk of breast cancer
Clomiphene
-SERM
-stimulate oculation
Fulvestrant
-SERD
-tx for breast cancer in pt resistant to tamoxifen
SERMS
-tamoxifen
-toremifene
-ospemifene
-raloxifene
-bazedoxifene
-clomiphene
Aromatase inhibitors
-Anastrazole
-Letrozole
-Exemestane
Gonadotropin preparations
-Menotropins
-Urofollitropin
-Follitropin
-Lutropin
-hCG
-Chorio
Inducing ovulation w gonadotropins
-use FSH during follicular phase
-add GnRH antagonist to prevent LH surge
Gonadotropins for male infertility
-LH and FSH
-inject hCG 8-12 weeks
GnRH analogs
-Gonadorelin, -elins
-IV every 1-4 hours
-pulsatile
-nonpulsatile inhibits FSH and LH = HYPOgonadism
GnRH ANATgonists
-Ganirelix
-Cetrorelix
-Abarelix
-Degarelix
Glucocorticoids
-stress hormones
-anti-inflammatory
-epinephrine
-cortisol
-NFkB = immunosuppression
Epinephrine
-B agonist
-break glycogen to release glucose
-GC
