wk3 11 - gord, dysmotility Flashcards
how does GORD occur 3
incompetent lower oesophageal sphincter
poor oesophageal clearance
barrier function/visceral sensitivity
associated symptoms of GORD
heartburn acid reflux dysphagia - odynophagia weight loss chest pain hoarseness coughnig waterbrash (saliva due to indigestion)
dyspepsia
indigestion
t/f barrets oesophagus may be reveresed from columnar epithelium back to squamous stratified
false
irreversible
3 main areas for management of GORD
symptom relief
healing oesophagitis
prevent complications
antacids are used in GORD as symptomatic relief. however what is the limitations
doesnt aid healing or prevent complicatiosn
t/f cimetidine is less effective than a placebo
true
used for rapid symptom relief
what type of drugs are cimetiidine and ranitidine
H2 antagonists
function of H2 receptor antagonists
blocks histamine reduces gastric acid production ]
lansoprazole can be used as pain relief for GORD, which dosage better, 15 or 30mg?
15mg
management of dysplasia of GORD q
surveillance - frequent endoscopic mucosal resection correct PPI dose radiofrequency ablation argon
examples of proton pump inhibitors, how do they work
lansoprazole
omeprazole
block enzymes reducing productioon of gastric acid
name for disease which there is no physical obstruction, yet there is a delay in gastric emptying
gastroperesis
associated symptoms of gastroparesis
feeling of fullness nausea vomiting weight loss upper abdominal pain
which drugs can cause gastroparesis
opiates
anticholinergics
cannabis
