wk 3 biochem recap Flashcards
where does fatty-acyl-CoA synthesis and activation occur
in cytoplasm
what allows fatty-acyl-CoA to be transported across membrane
carnitine
fatty acyl-CoA is converted to acetyl-CoA via
beta oxidation
malonyl CoA is
a precursor for fatty acyl-CoA (comes from citrate)
t/f lipids contain phosphate groups carbohys, proteins
true
fatty acids can be used in gluconeogenesis t/f
false
fatty acids have to be activated to acetyl-CoA
false
activated to acyl-CoA
where does beta oxidation occur (LIKELYQ)
mitochondrial matrix
products of beta oxidation (LIKELY Q)
1 acetyl-coa
1 FADh2
1 NAHD + H+
1 fatty acyl-CoA shortened by 2 carbons
number of cycles calculated by (LIKELYQ)
cycles= (no. of Carbon/2) - 1
purpose of ketone bodies in peripheral tissue
energy metabolism for brain/heart/renal under fasting conditions
where are ketone bodies formed
liver mitochondria (hypoglycaemia)
3 ketone bodies (LIKELYQ)
acetoacetate
alpha-3-hydroxy-butyrate
acetone
t/f ketone can lead to ketoacidosis
true
t/f ketone accumulates as a by-product of beta oxidation
true
under starved conditions
cofators for synthesis of fatty acids
NADPH
t/f there is alength consteain in fatty acid synthesis
true
stops at C-16
t/f AMP, gucagon, epinephrine inhibit acetyl CoA carboxylase activity
true
what is abundant when fatty acids in excess
palmitoyl CoA (inhibitis acetyl coA carboxyase
t/f if citrate stimulates aoollestericlly, then citrate helps insulin to stimualte the catalytic activity of acetyl-coA carboxylase
false
urea is synthesised from gaining 2 nitrogens. Where are both obtained
free ammonium
aspartic acid
t/f carbon skeletons of all amino acids can enter TCA
true
t/f removal of mino group only ooccurs in liver cells for amino acid catabolism
false
glucose travelled in blood via
GLUT2
glucose-6-phosphatase is used to catalyse
glucose-6-p to glucose
t/f gluconeogenesis is the reveral of glycolyss
false
glycogen is a polymer. what catalyst which allows 4 glucose molcules to bind
glycogenin protein
t/f glycogenin is rate limiting for glycogen production
true
can only join 4, glycogen synthase then required to join more glucose
t/f amino acids can serve as precursors for gluconeogenis
true
oxaloacetate
t/f glucose has to be bound to UDP before transferred onto glycogen
true
t/f glucose removws from glycogen as glucose-6-p
false
first phosphorylates as glucose-1-phosphate
