Drugs Flashcards
4 drug types which inhibit parietal cells secretion
parietal - acid PPIs (omeprazole) Muscarinic receptor antagonists H2 receptor antagonists NSAIDS
t/f warfarin can cause peptic ulcers
false
NSAIDS - drugs
when treating peptic ulcers, what 3 things will need to be considered
h.pylori? if so eradicate
incr mucosal strength
reduce HCL
name 2 mucosal strengtheners
ssucralfate
bismuth chealate
ranitidine
H2 receptor antagonist
reduces ACh and gastric acid secretion
4 types of antiemetic drugs
dopamine antagonists
5HT3 receptor antagonists
H1 receptor antagonists
Antimuscarinic
haloperidol prochlorperazine droperidol Chlorpromazine these are all
Dopamine antagonists
how does dopamine antagonists work, when would they be used
block chemoreceptor trigger zone (CTZ)
radiation/drug-induced sickness
which types of drugs end in ‘setron’
5ht3 antagonists
commmon side effect of Ondansetron
headache
other than ondansetron, give an example of a 5ht3 receptor antagonists
Gransetron
how does H1 receptor antagonists work
blocks H1 in vestibulei nuclei and NTSA
give an example of h1 antagonist and when it would be used
promethazine
(also cyclizine, cinnarizine)
most sickness, post op sickness
which h1 antagonist - promethazine, cyclizine, cinnarizine, is linked to menieres disease
cinnarizine
dicyclomine is what type of drug, when would it be used 2
antimuscarinic
motion sickness
IBS
antimuscarinic drugs (scopolamine, dicyclomine) have many adverse affects due to their interaction with the Para ANS/ what are they 4
blurred vision
urinary retention
xerostomia
sedation
triple threat therapy is used in chemo-induced emesis, what is this
5HT3 antagonist
Dexamethasone
Aprepitant
when would hyperemesis gravidarma occur
during pregnancy - intractable emesis ]
what is the 1st and 2nd line treatment for hyperemesis gravidarma
1st - H1 Antagonists (promethazine, cyclizine)
2nd - Dopamine ant. (prochloperazine, metoclopramide)
explain prokinetic drugs affect on GI and CNS
GI
- incr peristalsis, incr lower ooesophageal sphincter tone
CNS
blocks D2
give 2 examples of prokinetic drugs
domperidome
metoclopramide
4 types of laxatives
purgatives
softeners
bulk
osmotic
methylcellulose
bulk laxative, slow working, improves stool consistency
mg sulphate is what type of laxative
osmotic
incr peristalsis, rapid effect
docusate sodium is what type of laxative
softener
t/f mesalazine is a purgative
false
it is aminosalicylate
purgatives work by incr h20 and electrolyte, and peristalsis, give an example and a likely side effect
bisacodyl
ab cramp
mesalazine sulfalazine olsalazine balsalazide these are .... and used for
aminosalicylates
IBD flares
better in UC
IBS is treated using 3 types of drugs, what are they,
Anti-motility
Anti-spasmodic
Anti-depressent
Hyosine is an anti-motility agent t/f
false
anti-spasmodic
mebeverine
anti-spasmodic
give 3 anti-motility agents
codeine
diphinoxylate
loperamide
amitriptyline is
anti-depressant
when are bile acid sequestrants used 2
(prevent bile re-absorption)
hyperlipidemia
jaundice
3 examples of bile acid sequestrants
colesevelam
colestipol
colestyramine
