wk 7 5 LFTs Flashcards
other than ALT/AST what other enzymes studied in LFTs
GGT
Alkaline phosphatase
where else is alkaline phosphatase found
placenta
GGT indicates
alcholic liver disease
when are the transaminases released
in response to hepatocellular injury
where is ALT found in liver cells
near cytosol
biliary obstruction will coincid to how much ALT
> 1/2000 U/L (should revert back)
obstructive jaundice is seen as
less than 500 U/L (ALT)
half lives of ALT, AST and ALkaline phosphatase
…(27hr~)
…(17hr~)
1 week (slow rise)
what is bilirubin bound to
albumin
bilirubin is the breakdown of
Hb
liver is important for many clotting factors, which ones are fibrinogen/prothrombin
Factor I
Factor II
other than I and II, what other clotting factors produced
v viii ix x xii xiii
what does PT measure
conversion of PT - thrombin, relfect clotting time
elevated may reflect of reduced synthetic functionality
other causes of prolongation of PTb
drugs
bile malabsorption (causes relative vit K deficiency)
consumptive /congenital coagulopathy
areas needed in history to cover for liver
drugs (OTC, herbal, controlled, prescription)
pruritus, jaundice, arthralgi weight loss, xanthema fever, anorexia
parenteral exposures (IV) blood transfusions, intranasal, drugs, tattoos sexual history
travel history - timings, zoos, unusual hobbies
alcohol exposure - specific
occupation
temporal variation - itchy at night, fatigue in morning (cholestatic jaundice)
