wk 5 10 viral hepatitis

Question 1

how is hep a transmitted

Answer 1

faecal-oral spread
IV drug users
Gay men
Poor hygiene

Question 2

clinical presentation of Hep A

Answer 2

acute hepatitis - lasts for few days/weeks
no chronic infection
young (usually asymptomatic) /old

Question 3

suspected Hep A, what investigation

Answer 3

serology - clotted blood

Hep A IgM

Question 4

t/f clinical presentation of Hep E is similar to Hep A

Answer 4

true

become more common than HepA in UK

Question 5

Hep E cases are considered zoonoses, explain

Answer 5

acquired from animals

usuallly pigs

Question 6

t/f Hep E can lead to chronic infection

Answer 6

true

only in immunocompromised

Question 7

Hepp D requires another virus, which hepatitis is this

Answer 7

Hep B

Question 8

how is Hep B transmitted

Answer 8

sex
mother - child
blood (needle prick injury, IV users, tattoos)

Question 9

which antigen is present in blood of all infected Hep B patients

Answer 9

HBsAg

Question 10

other than HBsAg, what would be found in highly infectious individuals

Answer 10

Hep B virus DNA

Hep B E Antigen (HBeAg)

Question 11

if recently infected by Hep B, what is most likely found

Answer 11

Hep B IgM

Question 12

ALT is a biochemical marker for

Answer 12

inflammation in liver

Question 13

t/f there is a post-exposure prohylaxis for Hep B

Answer 13

true

given if partner recently diagnosed, may have spread

Question 14

t/f vaccine for Hep C

Answer 14

false

Question 15

if chronic infection arises, what can this lead to for Hep A

Answer 15

chronic hepatitis - may resolve/ lead to cirrhosis - may lead to chronic liver failure or cancer

Question 16

what defines chronic infection

Answer 16

6 months of infection

Question 17

t/f spontaneous cure in hep C is not uncommon

Answer 17

false
once chronic infection, spontaneous not seen

seen in HEp B

Question 18

time from chronic infection to cirrhosis/hepatocellular carcinoma

Answer 18

cirrhosis >20yrs

Hepatocellular carcinoma > 30yrs

Question 19

what test is given for patients at risk of Hep C/ signs of chronic liver disease

Answer 19

test for antibody to Hep C virus

Question 20

test for antibody in Hep C is positiv,e, what is then tested

Answer 20

test for hep c virus RNA by PCR

Question 21

t/f no vaccine for Hep C

Answer 21

true

Question 22

which 2 infections are cirrhotic patients more likely to ge

Answer 22

influenza and pneumococcal infections

screen for carcinoma too

Question 23

therapy for chronic Hep B

Answer 23

suppressive antiviral drug
entecavir
tenofovir

may be given peginterferon alone

Question 24

duration of treatment of Hep C

Answer 24

12 weeks