wk 5 10 viral hepatitis Flashcards
how is hep a transmitted
faecal-oral spread
IV drug users
Gay men
Poor hygiene
clinical presentation of Hep A
acute hepatitis - lasts for few days/weeks
no chronic infection
young (usually asymptomatic) /old
suspected Hep A, what investigation
serology - clotted blood
Hep A IgM
t/f clinical presentation of Hep E is similar to Hep A
true
become more common than HepA in UK
Hep E cases are considered zoonoses, explain
acquired from animals
usuallly pigs
t/f Hep E can lead to chronic infection
true
only in immunocompromised
Hepp D requires another virus, which hepatitis is this
Hep B
how is Hep B transmitted
sex
mother - child
blood (needle prick injury, IV users, tattoos)
which antigen is present in blood of all infected Hep B patients
HBsAg
other than HBsAg, what would be found in highly infectious individuals
Hep B virus DNA
Hep B E Antigen (HBeAg)
if recently infected by Hep B, what is most likely found
Hep B IgM
ALT is a biochemical marker for
inflammation in liver
t/f there is a post-exposure prohylaxis for Hep B
true
given if partner recently diagnosed, may have spread
t/f vaccine for Hep C
false
if chronic infection arises, what can this lead to for Hep A
chronic hepatitis - may resolve/ lead to cirrhosis - may lead to chronic liver failure or cancer
what defines chronic infection
6 months of infection
t/f spontaneous cure in hep C is not uncommon
false
once chronic infection, spontaneous not seen
seen in HEp B
time from chronic infection to cirrhosis/hepatocellular carcinoma
cirrhosis >20yrs
Hepatocellular carcinoma > 30yrs
what test is given for patients at risk of Hep C/ signs of chronic liver disease
test for antibody to Hep C virus
test for antibody in Hep C is positiv,e, what is then tested
test for hep c virus RNA by PCR
t/f no vaccine for Hep C
true
which 2 infections are cirrhotic patients more likely to ge
influenza and pneumococcal infections
screen for carcinoma too
therapy for chronic Hep B
suppressive antiviral drug
entecavir
tenofovir
may be given peginterferon alone
duration of treatment of Hep C
12 weeks
