wk 4 5 - colorectal pathology 2

Question 1

histology of diverticulae

Answer 1

some mucosa
not neoplastic
neuromuscular mechanical process, histology will look normal

Question 2

2 main factors for developing diverticular disease

Answer 2

low fibre diet

incr intralumenal pressure

Question 3

t/f symptoms only occur if complicated diverticulae

Answer 3

true

surgery required

Question 4

lack of fibre causes

Answer 4

colon to use a greater force to move bowels along

incr pressure

Question 5

5 complications of diverticulae

Answer 5

inflammation 
ruptrue
abscess
fistula 
haemorrhage

Question 6

what is seen histologically in ischaemia of lamina propria and crypts q

Answer 6

withering crypts

smudging of lamina propria

Question 7

ischaemia of large bowel more likely to occur `

Answer 7

left side

Question 8

causes of ischaemia

Answer 8

ahterosclerosis 
a fib 
vasculitis
idiopathic inflammatioin 
hypovolaemic shock

Question 9

complications of large bowel ischaemic colitis

Answer 9

bleeding
rupture
stricture

Question 10

explosive lesions on mucosa is indicative of

Answer 10

antibiotic-induced ‘pseudomembranous’ colitis

Question 11

other than explosive lesions of mucosa, what is characteristics of pseudomembranous colitis

Answer 11

explosive fibrinopurulent exudate on surface (histology)
on broad spectrum antibiotics
c.difficile selected out
massive diarrhoa and bleeding

Question 12

how to treat pseudomembranous colitis

Answer 12

flagyl/vancomycin

may need colectomy

Question 13

t/f normal mucosa is seen in patients with watery diarrhoea

Answer 13

true

Question 14

collagenous colitis can be defined in histology through

Answer 14

thick collagen band close to lumen, subepithelial

Question 15

t/f no chronic structural changes seen in collagenous colitis

Answer 15

true

Question 16

which colitis looks similar to coeliac disease histologically, due to incr in presence of lymphocytes

Answer 16

lymphocytic colitis

raises possibility of coeliac disease

Question 17

t/f there is a thickening of basement membrane in lymphocytic colitis

Answer 17

false

only incr in intraepithelial lymphos

Question 18

disturbed archiecture
random organisation 
not much inflammationi 
spaces in lamina propria 
this indicates

Answer 18

radiation colitis

prev history of cervical carcinoma

Question 19

colitis which is iatrogenic

Answer 19

radiation colitis

Question 20

other than infection, what can cause acute colitsi

Answer 20

drugs (rarely)
ischaemia
endoscopy