Week 7: Chapter 20 Flashcards
Drugs That Effect Blood Clotting
What is the main purpose of anticoagulation?
To prevent clots from forming where they are not needed
Which condition is a common indication for the use of an anticoagulant drug?
Atrial fibrillation
Which of the following drugs or supplements makes the risk for bleeding worse when a patient is also taking an anticoagulant drug?
- Aspirin
- Gingko biloba
- St. John’s Wort
What agent is used as an antidote for a warfarin (Coumadin) overdose?
Vitamin K
Which action is essential before beginning continuous IV heparin therapy?
Get an accurate baseline patient weight
Which anticoagulant drug must be avoided during pregnancy because it can cause birth defects in the fetus?
Warfarin (Coumadin)
Which lab test result indicates that an antiplatelet drug is effective?
International Normalized Ratio (INR) is increasing
What agent is used as an antidote for a heparin overdose?
Protamine sulfate
After bleeding, what is the most common A/E of most antiplatelet drugs?
Decreased platelet count
Which action is important to prevent to prevent losing any part of the drug dose when administering low molecular weight heparin?
Not expelling the air bubble before injecting the drug
Why is the antiplatelet effect of aspirin longer lasting than that of other NSAIDs?
Aspirin irreversibly inhibits the production of TXA2, whereas NSAIDs cause reversible inhibition of this substance
Why is it important to teach the patient starting on the anticoagulant warfarin (Coumadin) to limit his/her intake of leafy green vegetables?
These foods contain vitamin K, which can reduce the effects of warfarin
What is the major MOA that allows thrombolytic drugs to dissolve clots?
Increasing the blood level of the enzyme plasmin
Which problems, conditions, or drugs are absolute contraindications for thrombolytic therapy?
- Recent head trauma
2. Undergoing cancer chemotherapy
What is the intended response when a patient is prescribed epoetin alfa (Epogen)?
RBC levels normalize