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Fundamentals 1 > Week 6 Pharmacokinetics > Flashcards

Week 6 Pharmacokinetics Flashcards

1
Q

Steady state concentration definition + definition

A

When dosing rate is equivalent to elimination rate

ex: 10 mg / min

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2
Q

How many half lives to be eliminated from steady state?

A

4-5

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3
Q

How many half lives to reach steady state?

A

4-5

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4
Q

What does increasing infusion rate do?

A

increases steady state concentration

*has no effect on half-life/time to reach steady state concentration

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5
Q

What effects half lives?

A

Dependent on volume of distribution and clearance

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6
Q

Increased Vd and half life and SSc

A

Increased half life

takes longer to reach SSc

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7
Q

Increased clearance and half life

A

Decreased half life

takes less time to reach SSc

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8
Q

Increased clearance rate and maintenance dose

A

Higher maintenance dose

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9
Q

Increased bioavailability and maintenance dose

A

decreased maintenance dose

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10
Q

In renal / hepatic failure, what should be adjusted?

A

decrease maintenance dose

no change to loading dose

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11
Q

What is loading dose not dependent on?

A

loading dose is not dependent on clearance

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12
Q

What is maintenance dose not dependent on?

A

volume of distribution

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13
Q

What 2 factors is loading dose dependent on?

A

volume of distribution

bioavailability

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14
Q

Loading dose if bioavailability decreases

A

higher loading dose

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15
Q

Loading dose if Vd decreases

A

smaller loading dose

*more Vd in serum

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16
Q

What do changes in half life effect?

A

total time to reach steady state concentration

17
Q

therapeutic window

A

difference between toxic threshold and therapeutic threshold

18
Q

Why is thyroid’s dosing weird?

A

because it has a small therapeutic window

19
Q

If your dose interval is below 4 hours, what should you do?

A

give the drug IV

20
Q

What might make us want to give a smaller loading dose?

A

a small therapeutic window

21
Q

Why do you have to wait to check TSH levels after starting thyroid meds?

A

thyroid meds have long half life

22
Q
A

Fundamentals 1 (29 decks)

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