Breast Lumps / Disorders

Question 1

What is a normal mammogram?

Answer 1

fat is dark gray

glandular tissue is white

Question 2

What color is cancer on mammography?

Answer 2

white

Question 3

Fibroadenoma

Answer 3

benign

make up 50% of breast masses in females below 30

Question 4

Molecular etiology for fibroadenoma

Answer 4

MED12

Question 5

Does risk of breast cancer increase with fibroadenoma?

Answer 5

yes, about 2x increased risk

Question 6

Fibroadenoma radiographic findings

Answer 6

oval, circumscribed

can calcify overtime

Question 7

Breast abscess

Answer 7

benign

common in lactation

typically near the nipple

Question 8

Paget’s

Answer 8

malignant

non-invasive breast cancer

Question 9

Molecular makeup of Paget’s commonly

Answer 9

BRCA 1/2

higher prevalence in Ashkenazi Jewish and African descent

often HER2+

Question 10

DCIS

Answer 10

malignant

generally no symptoms

calcifications

Question 11

DCIS molecular makeup

Answer 11

BRCA 1/2

Question 12

Invasive ductal carcinoma

Answer 12

rock hard mass, if palpable

Question 13

Molecular makeup of invasive ductal carcinoma

Answer 13

BRCA 1/2

Question 14

Invasive lobular carcinoma

Answer 14

single file growth

does NOT have calcifications which can make it harder to detect

Question 15

Molecular makeup of invasive lobular carcinoma

Answer 15

CDH1 germline

e-cadherin somatic mutations

ER/PR +

Question 16

Galactocele

Answer 16

benign

inflammed ducts normally in lactating women

often painless

Question 17

Fat necrosis

Answer 17

benign

commonly caused by minor trauma

Question 18

What is missed on mammography more? ILC or IDC?

Answer 18

ILC due to heterogenous nature