Toxin review

Question 1

Exotoxins that are pore-forming

Answer 1

Alpha toxin from staph aureus

-lysin toxins

Question 2

Cholera toxin

Answer 2

AB5 toxin

activates Gs which leads to increase in cAMP

ADP-ribosylation of GTPase

Question 3

Pertussis toxin

Answer 3

AB5 toxin

targets Gi

Gi becomes locked (GDP-bound) which results in increased levels of cAMP

Question 4

Which toxins are AB5 toxins?

Answer 4

Can Pat Shack Sam?

cholera

petrussis

shiga

shiga-like

Question 5

Which toxins are AB toxins?

Answer 5

Danny Easily Bothers Tammy

diptheria

exotoxin A

botolium toxin

tetani toxin

Question 6

Heat labile toxin

Answer 6

increase cAMP

Question 7

Heat stable toxin

Answer 7

increase cGMP

Question 8

Shiga toxin

Answer 8

leads to HUS

increases 38s rRNA

Question 9

Diptheria toxin

Answer 9

AB toxin

ADP ribosylation of EF-2

Question 10

shiga-like toxin

Answer 10

produced by EHEC

AB5 toxin

HUS

inactivates 28s rRNA

Question 11

Which 2 toxins inactivate 28S rRNA?

Answer 11

shiga toexin

shiga-like toxin

Question 12

exotoxin A

Answer 12

produced by P. aeruginosa

ADP ribosylation of EF-2

Question 13

botulinum toxin

Answer 13

AB toxin

targets SNARE proteins to block acetylcholine release

leads to flaccid paralysis

Question 14

tetanus toxin

Answer 14

AB toxin

binds to inhibitory transmitters (GABA and glycine)

results in spasm

Question 15

CDT

Answer 15

C. diff transferase toxin

ADP-ribosylation of G-actin

Question 16

TcdB

Answer 16

C. diff toxin B

glycosylation of GTP-binding proteins

targets CSPG4 and FZD

Question 17

TcdA

Answer 17

C. diff toxin A

glycosylation of GTP-binding proteins

Question 18

C Diff Transferase Toxin (CDT)

Answer 18

ADP-ribosylation of G-Actin prevents its polymerization

results in cytoskeletal defects and cell death