Hematopoiesis Flashcards
multipotent stem cell
able to give rise to multiple cells within a lineage
more limited than a pluripotent cell
example of a multipotent stem cell
HSC
pluripotent stem cell
can give rise to all cells that make up the human body
What cells develop in the bone marrow?
B-cells and myeloid cells
What cells develop in the thymus?
T-cells
What type of cell develops into a RBC?
erythocyte
EPO
a growth factor that increases RBC production
TPO
increases platelet production
G-CSF
stimulates granulocytic progenitors in the marrow that will increase neutrophil production
a cytokine
GM-CSF
simular to G-CSF but stimulates the production of more types of immune cells than just neutrophils
also produces macrophages and eosinophils
a cytokine
What type of cell are eosinophils and basophils?
myeloid
What type of cell are neutrophils?
myeloid
What type of cells are RBCs and platelets?
myeloid
What type of cells are monocytes?
myeloid
What type of cells are lympoid cells?
B-cells, T-cells, NK cells and dendritic cells
Which diseases arise due to the replacement of normal hematopoietic cells?
Fibrosis, leukemia, neuroblastoma, TB
Granulomatous infection
TB
Metastatic malignancy associated with replacement of normal hematopoietic cells
neuroblastoma
primary hematopoietic maliganct
leukemia
What are two ways complete loss of stem cells can happen?
- DNA damage (inborn or acquired)
- Autoimmune destruction of stem cells
What inborn DNA disease can cause loss of stem cells?
Fanconi anemia
How can stem cells be temporarily depressed?
- viral supression
- medications
What medications can suppress stem cells?
AEDs
What virus can suppress stem cells?
EBV
