Hematopoiesis

Question 1

multipotent stem cell

Answer 1

able to give rise to multiple cells within a lineage

more limited than a pluripotent cell

Question 2

example of a multipotent stem cell

Answer 2

HSC

Question 3

pluripotent stem cell

Answer 3

can give rise to all cells that make up the human body

Question 4

What cells develop in the bone marrow?

Answer 4

B-cells and myeloid cells

Question 5

What cells develop in the thymus?

Answer 5

T-cells

Question 6

What type of cell develops into a RBC?

Answer 6

erythocyte

Question 7

EPO

Answer 7

a growth factor that increases RBC production

Question 8

TPO

Answer 8

increases platelet production

Question 9

G-CSF

Answer 9

stimulates granulocytic progenitors in the marrow that will increase neutrophil production

a cytokine

Question 10

GM-CSF

Answer 10

simular to G-CSF but stimulates the production of more types of immune cells than just neutrophils

also produces macrophages and eosinophils

a cytokine

Question 11

What type of cell are eosinophils and basophils?

Answer 11

myeloid

Question 12

What type of cell are neutrophils?

Answer 12

myeloid

Question 13

What type of cells are RBCs and platelets?

Answer 13

myeloid

Question 14

What type of cells are monocytes?

Answer 14

myeloid

Question 15

What type of cells are lympoid cells?

Answer 15

B-cells, T-cells, NK cells and dendritic cells

Question 16

Which diseases arise due to the replacement of normal hematopoietic cells?

Answer 16

Fibrosis, leukemia, neuroblastoma, TB

Question 17

Granulomatous infection

Answer 17

TB

Question 18

Metastatic malignancy associated with replacement of normal hematopoietic cells

Answer 18

neuroblastoma

Question 19

primary hematopoietic maliganct

Answer 19

leukemia

Question 20

What are two ways complete loss of stem cells can happen?

Answer 20

1. DNA damage (inborn or acquired)
2. Autoimmune destruction of stem cells

Question 21

What inborn DNA disease can cause loss of stem cells?

Answer 21

Fanconi anemia

Question 22

How can stem cells be temporarily depressed?

Answer 22

1. viral supression
2. medications

Question 23

What medications can suppress stem cells?

Answer 23

AEDs

Question 24

What virus can suppress stem cells?

Answer 24

EBV