VITAMINS REVAMPED Flashcards

1
Q

folic acid antagonists are competitive inhibitors of this enzyme

A

folic reductase

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2
Q

Test for vit b6 deficiency

A

tryptophan load test

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3
Q

Vitamin needed in the conversion of

homocysteine 🡆 methionine

A

B9

B12

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4
Q

major excretory form of vit c

A

oxalic acid

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5
Q

if thiamine is deficient, what sugars will tend to accumulate in the blood and urine

A

ribose and xylulose

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6
Q

people who are found of eating raw fish, clams and oysters may develop deficiency in what vitamine

A

thiamine vit b1

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7
Q

macrocytic anemia WITHOUT neurological symptoms is a deficiency manifestation of

A

folic acid vit b9

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8
Q

coenzyme of the major anaphlerotic reaction and conversion of glutamic acid to GABA

A

vitamin b6 pyridoxine

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9
Q

involved in the synthesis of cholesterol and extramitochrondial lipogenesis

A

vit b5 pantothetic acid

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10
Q

coenzyme of transammination reactions. needed in the fixation of CO2 at carbon 6 of the purine ring and needed in the activation of folic acid

A

vit b7 biotin

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11
Q

is folic acid an energy releasing vitamin

A

nope

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12
Q

form of folic acid that is involved in the catabolism of histidine

A

methyl FH4

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13
Q

with defective bone mineralization, poor wound healing and abnormal collagen formation

A

scurvy

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14
Q

coenzyme of vit12 is also called

A

5 DEOXYADENOSYLCOBALAMIN and biologic grignard reagent

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15
Q

swelling of costochondral junction is a deficiency manifestation of

A

vit c

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16
Q

patient with impaired cognitive abilities and peripheral neuropathy. also a chronic alcoholic and has not been eating well for several weeks. this patient most likely is deficient in

A

thiamine vit b1

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17
Q

lactic acidosis develops in thiamine deficiency because

A

pyruvate can not be converted to acetyl COA

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18
Q

THIS VITAMIN ACTS AS A COENZYME IN THE RATE LIMITING STEP IN HEME SYNTHESIS

A

b6 or pyridoxal phosphate

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19
Q

🤢 3 key manifestations of pantothenic acid or b5 deficiency

A

easy fatigability, atrophy of the adrenal glands and anemia

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20
Q

enzyme assayed to know the status of b6 pyridoxine in the body

A

aminotransferase

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21
Q

exact role for vit c in collagen synthesis

A

coenzyme for hydroxylation of lysine and proline

22
Q

deficiency of this vitamin may lead to oxalate stone formation

A

vit b6 or pyridoxine

23
Q

enzyme assayed to determine status of riboflavin b2 in the body

A

glutathione reductase

24
Q

megaloblastic anemia is a deficiency manifested in

A

folic acid and cobalamin

25
Q

rosary beads on the chest is a deficiency manifestation of

A

vit C and D

26
Q

bone calcium-binding proteins require vitamin K for their synthesis

A

osteocalcin and bone matric GLA protein

27
Q

vitamins that becomes deficient if there is complete obstruction of the common bile duct

A

retinol, calcitriol, vitamin E and farnoquinone

-frec-

28
Q

vitamins that are excreted mainly by the kidneys

A

riboflavin and niacin

29
Q

enzymes that requires TTP as coenzyme

A

alpha ketoglutarate dehydrogenase and pyruvate dehydrogenase

30
Q

atrophy of germinal epithelium in males and increased susceptibility to infection and also with with bitots spots

A

vitamin A deficiency

31
Q

enzymes that need b2 as coenzyme

A

xanthine oxidase, glycerophosphate dehydrogenase, glutathione reductase and pyruvate dehydrogenase
xo, gpd, gd, pd

32
Q

proteins that are needed in the transport of vit A thru plasma and to the cells

A

retinol binding protein and pre-albumin

33
Q

dermatitis is a deficiency manifestation of

A

Vit b6, and riboflavin

34
Q

pathways utilizing NAD as coenzyme

A

oxidative deamination and gluconeogenisis

35
Q

forms of vit A that regulate growth, development and tissue differentiation

A

All-trans-retinoic acid and 9 cis retinoic acid

36
Q

substances needed in the conversion of beta carotene to vit a

A

insulin, thyroid hormone, zinc, vitamin e

37
Q

drugs that may interfere with folate metabolism

A

anticonvulsants and oral contraceptives

38
Q

pathways where biotin is needed as coenzyme

A

fatty acid biosynthesis and beta oxidation of odd numbered fatty acids

39
Q

pathways that require pantothenic acid

A

krebs, cholesterole synthesis, porphyrin synthesis, extramitochondrial lipogenesis

40
Q

vitamins that are needed to prevent homocysteine in the body

A

⮞ B3 (niacin)
⮞B6 (P,P,P)
⮞ B9 (folic acid)
⮞B12 (cobalamine)

41
Q

synthesized by bacteria flora in the gut

A

⮞ Vit K

⮞ B1,2,7,9,12

42
Q

Natural vitamins?

A

⮞ Vit D, K

⮞ B1,2,7,9,12

43
Q

RBC maturation vitamin

A

Vit B12

44
Q

vitamin that regenerates vitamin E

A

VIT C

45
Q

Vitamin E enhances ______ 🡆 increase risk of bleeding

A

warfarin (anti-coagulant)

46
Q

processes of oxidation

A
  1. gain O2
  2. lose H+
  3. lose e-
47
Q

vitamin needed for conversion of

homocysteine 🡆 cysteine

A

VIT B6

48
Q

cysteine + homocysteine =

A

⮞ pyruvate
⮞ a-ketobutyric acid
⮞ cysteine

49
Q
Clinical manifestations of: 
⮞ cheesy odor of breath 
⮞ accumulation of isovaleryl coA
⮞deficiency: Isovaleryl coA DH 
⮞ inborn error assoc. with Leucine
A

Isovaleric Acidemia

50
Q

HMG CoA (3-hydroxy-3-methylglutaryl coenzyme A) is derived from Leucine and why is it important?

A

⮞ It serves as link bet. lipid and protein metabolism
⮞ intermediate ng cholesterol synthesis
⮞ intermediate ng ketogenesis

51
Q

VIT E deficiency 🡆 fat malabsorption such as?

A

⮞ chronic pancreatitis
⮞ cystic fibrosis
⮞ abetalipoproteinemia

52
Q
B1 🡲 DECARBOXYLATION (transfer 2C units)
B3 🡲 reduction-oxidation reactions
B6 🡲 transamination 
B7 🡲 carboxylation 
B9 🡲 \_\_\_\_\_\_\_
A

transfer of 1 carbon unit