Conference: Telomerase, aging & cancer

Question 1

short thymine-guanine sequence, replication and stability of the chromosome

Answer 1

Telomere

Question 2

adenine-thymine Base pairs, attachment site of mitotic spindles

Answer 2

Centromere

Question 3

this requires RNA primers attaching ahead on the lagging strand

Answer 3

synthesis of Okazaki Fragments

Question 4

this state limits the replicative capacity of cells, thus preventing the proliferation of cells

Answer 4

a state of irreversible growth arrest (cellular senescence)

Question 5

period of little proliferation

Answer 5

phase 1 of cellular senecence

Question 6

rapid proliferation and cells divide in culture

Answer 6

phase 2 of cellular senecence

Question 7

cells start dividing slower, and gradually proceeds a complete stop

Answer 7

phase 3 of cellular senecence

Question 8

limit of cellular replicative capacity, that amounts to 50 divisions only

Answer 8

hayflick limit

Question 9

mechanism where RNA primers start DNA replication

Answer 9

telomeric shortening

Question 10

results of a sugar reducing molecule, such as fructose or glucose bonding to protein

Answer 10

glycation

Question 11

transglutaminase (tTGase) mediated macromolecule crosslinking of histone

Answer 11

Crosslinking

Question 12

what stabilizes the telomere

Answer 12

T-LOOP NIGGA

Question 13

how can telomerase be used to extend cellular life span

Answer 13

RNA + hTERT gene product, they could immortalize cells without turning them cancerous