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BIOCHEMISTRY > Lipid metabolism > Flashcards

Lipid metabolism Flashcards

1
Q

receptors for chylomicron remnants

A

ApoE specific

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2
Q

VLDL remnant maybe converted into

A

LDL

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3
Q

chylomicron remnants are CATABOLIZED where

A

liver

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4
Q

elevated plasma level projects against artherotherosclerosis

A

HDL

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5
Q

cholesterol is transported from liver to extrahepatic tissues

A

LDL

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6
Q

triglycerides are transported from liver to extrahepatic tissues

A

VLDL

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7
Q

nascent chylomicron receives apolipoproteins C& E from

A

HDL

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8
Q

apolipoprotein B-100 is present in

A

VLDL&LDL

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9
Q

apolipoprotein B-48 is present in

A

chylomicrons

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10
Q

familial hypercholesterolemia is associated with

A

increased LDL concentration

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11
Q

conversion of fatty acyl-CoA derivative having 2 more carbon atoms involves as acetyl donor

A

Malonyl-CoA

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12
Q

the rate limiting step of cholesterol biosynthesis is

A

HMG CoA reductase

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13
Q

compound normally used to conjugate bile acids is

A

glycine

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14
Q

B-oxidation of fatty acid chain produces

A

propionyl CoA

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15
Q

chain elongation of fatty acids occurring in mammalian liver takes place in which of the following subcellular factions of the cell

A

microrosomes

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16
Q

LCAT is

A

lecithin cholesterol acyl transferase

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17
Q

the protein which is infact a multifunctional enzyme complex in higher organism is

A

fatty acid synthesis

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18
Q

class of lipoproteins having a beneficial effect in artherosclerosis is

A

HDL

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19
Q

the major source of cholesterol in arterial smooth muscle cells is from

A

LDL

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20
Q

long chain fatty acyl CoA esters are transported across the mitochondria membrane by

A

carnitine

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21
Q

the acetyl CoA formed on B-oxidation of all chain fatty acids is metabolized under normal circumstances to

A

CO2 and water

22
Q

in B-oxidation of fatty acids, what are utilized as coenzymes

A

FAD & NAD

23
Q

the most important sources of reducing equivalents for FA synthesis in the liver is

A

HMP-shunt

24
Q

as a result of each oxidation a long chain fatty acid is cleaved to give

A

an acid with Z-carbon less & acetyl CoA

25
Q

committed step in the biosynthesis of cholesterol from acetyl CoA is

A

formation of mevalinate from HMG CoA

26
Q

Acyl carrier protein is involved in the synthesis of

A

fatty acid outside the mitochondria

27
Q

ligated triacyglycerols are emulsified in the intestine by

A

bile salts

28
Q

the key enzyme in the regulation of fatty acid synthesis is

A

Acetyl-CoA carboxylase

29
Q

in the intestine, the dietary fat are hydrolized by

A

pancreatic lipase

30
Q

chain elongation of fatty acids occurring in mammalian liver takes place in which of the following subcellular fractions of the cell

A

microsomes

31
Q

B-oxidation of odd-carbon fatty acid chain produces

A

propionyl CoA

32
Q

long chain fatty acids enters mitochondria by

A

combing with carrier carnite

33
Q

HMG-CoA reductase is rate limiting enzyme of

A

cholesterol synthesis

34
Q

ketone bodies is synthesized from

A

Acetyl-Coa

35
Q

during starvation ketone bodies are synthesized in

A

Liver

36
Q

low carb diet with bad breath is due to

A

increased beta oxidization due to increased activity of hormone sensitive lipase with subsequent increased in ketone bodies in plasma

37
Q

the reducing equivalents necessary for fatty acid synthesis are produced during the conversion of

A

glucose-6-phosphate to ribose-5-phosphate

38
Q

TRUE of fatty acid synthase enzyme complex

A

The monomers are arranged in a head to tail configuration

39
Q

The phosphopanthetheine side chain is part of which sub-unit of fatty acid synthase enzyme complex

A

acyl carrier protein

40
Q

The committed step for the Beta-oxidation of FAs is inhibited by increased concentration of:

A

malonyl-coA

41
Q

The complete ATP yield of a saturated C16 FA is

A

106

42
Q

Condition that accelerates ketogenesis

A

decreased insulin/glucagon ratio

43
Q

Ketone bodies can be utilized by extra-hepatic tissues because of this enzyme

A

succinyl coA acetoacetate coA

SCAC

44
Q

This disease results from the accumulation of phytanic acid in the brain and kidneys of patients:

A

Refsums disease

45
Q

TRUE regarding apo-proteins

A

Apo D is present exclusively in HDL

46
Q

The concentration of this lipoprotein is inversely related to the incidence of coronary artery disease

A

HDL(2)

47
Q

Which receptors are actively involved in reverse cholesterol transport?

A

SR-B1

48
Q

The only part of an odd-chain fatty acid that is glucogenic is:

A

propionyl coA

49
Q

A patient with phenylketonuria has fair skin and blue eyes due to low levels of

A

tyrosine

50
Q

Thromboxane
⮞ stimulates _________
⮞ vaso______

A

⮞ stimulates platelet aggregation

⮞ vasoconstriction

51
Q

Prostacyclin
⮞ Inhibit _______
⮞ vaso________

A

⮞ Inhibits platelet aggregation

⮞ vasodilation

BIOCHEMISTRY (29 decks)

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