Nucleic acid metabolism

Question 1

What amino acid starts the sequence of protein synthesis?

Answer 1

Methionine

Question 2

A point mutation that produces a stop codon on the mRNA

Answer 2

non-sense mutation

Question 3

DNA molecule produced by HOOGSTEEN pairing

Answer 3

Triplex DNA

Question 4

In the nucleotide sequence, within a gene that is removed by process of RNA maturation during transcription:

Answer 4

INTRON

Question 5

________ breaks phosphodiester bond

Answer 5

DNA topoisomerase

Question 6

Regarding the formation of the replication fork, what processes are involved?

Answer 6

Helicase unwinding DNA

Primase synthesize RNA primer

Question 7

what enzyme is needed to form Deoxynucleoside phosphate from nucleoside diphospate?

Answer 7

Ribonucleotide reductase

Question 8

What is the end-product of Uridine Monophosphate catabolism?

Answer 8

B-alanine

Question 9

What is the end-product of Thymidylate catabolism?

Answer 9

B-aminoisobutyrate (BAIB)

Question 10

The enzyme for the committed step to synthesize purine is:

Answer 10

glutamine-PPRP aminotransferases

Question 11

What is the first purine formed in Purine synthesis?

Answer 11

PRPP

Question 12

The ff CARBON is contributed by a FOLATE co-factor:

Answer 12

C1

C4,5,6

Question 13

What is the committed step in purine synthesis?

Answer 13

Glutamine + PRPP -> Glutamine + 5-phospo-B-D-ribosylamine

Question 14

Cytosine is formed from Uracil by the enzyme:

Answer 14

URACIL -> Uracil deaminase -> CYTOSINE

Question 15

Orotate MonoPO4 received its PO4 molecule from:

Answer 15

cAMP

Question 16

Enzyme for the committed step to form Orotate, the intermediate of anabolism of pyrimidine is:

Answer 16

Di-hydroorotase

Question 17

Pyrimidine that can be used to make other pyrimidine bases is

Answer 17

Uracil

Question 18

The synthesis of a pyrimidine requires

Answer 18

glutamine, carbomyl phosphate, aspartate

Question 19

source of ribose

Answer 19

pentose phosphate shunt

Question 20

Which pathway recycles free bases from catabolic reactions?

Answer 20

Salvage pathway

Question 21

5-membered ring sugar has an -H in C2

Answer 21

Deoxynucleotide

Question 22

Precursor of TMP

Answer 22

dUMP