oncogenesis/signaling

Question 1

phosphorylation of PRB results to

Answer 1

cell cycle progression

Question 2

provides the pivotal decisional checkpoint in the fate of the stimulus

Answer 2

BCL-2

Question 3

Apoptotic pathway important after chemotherapy

Answer 3

p53-modified

Question 4

the activity of this Cyclin complex results to chromosome condensation

Answer 4

cyclin D/cdk-1

Question 5

true to molecular carcinogenesis

Answer 5

there is loss in function of oncogene

Question 6

viral oncoprotein which facilitates degradation of p53

Answer 6

E6

Question 7

true or false. APC in familial Adenomatous polyposis is an example of oncogene

Answer 7

True

Question 8

true or false. gene amplification and formation of double minutes is an example

Answer 8

True

Question 9

an adaptor protein which facilitates hydrolysis of GDP to GTP to form the active GTP-Rau complex in the RTX pathway

Answer 9

GEF

Question 10

a second messenger which activates Kinase C Downstream in inositol phospholipid

Answer 10

DAG

Question 11

which component of the RTK pathway functions as guanine exchange factor (GEF)

Answer 11

Sos

Question 12

true or false. the endpoint of GPCR is increased concentration of second messengers

Answer 12

True

Question 13

is the G protein involved in phospholipid signaling pathway Trimeric

Answer 13

yes

Question 14

does Ras transiocates to the nucleus

Answer 14

noo

Question 15

this enzyme activates production of IP3

Answer 15

Kinase C

Question 16

a protein kinase which directly activates MAP kinase in the MAP kinase pathway

Answer 16

MEK

Question 17

this links cAMP to transcription in the nucleus

Answer 17

CAPK

Question 18

what activates the CYCLIN/CDK

Answer 18

VEGF

Question 19

is G1/S cell cycle checkpoint regulated mainly by intracellular signals

Answer 19

yup

Question 20

true or false. in knudson’s 2 hit hypothesis. the second hit is gross chromosomal loss

Answer 20

true

Question 21

when RRB is inhibited, PRB is

Answer 21

in the phosphorylated state

Question 22

provides the pivotal decisional checkpoint in the fate of the cell after a death stimulus

Answer 22

BCL-2

Question 23

apoptotic pathway important after chemotherapy and radiation

Answer 23

p35-mediated

Question 24

the activity of this cyclin complex results to chromosome condensation

Answer 24

cyclin B/cbk1

Question 25

the single most common genetic change in human neoplasia involves

Answer 25

p53

Question 26

viral oncoprotein which facilitates degrdation of

Answer 26

E6

Question 27

the enzyme which activates production of P37

Answer 27

phospholipase C

Question 28

which cdk-inhibitor is being activated by p53

Answer 28

mutator gene

Question 29

mutation in which gene family may lead to formation of micro organelle insolubility

Answer 29

tumor suppressor gene

Question 30

viral oncoprotein that inhibits pRB

Answer 30

p21

Question 31

stage in chemical carcinogenesis which is organelle and reversable

Answer 31

promotion

Question 32

tax protein is responsible for the oncogenic effect of which virus

Answer 32

hepatitis b

Question 33

philadelphia chromosome in cml is due to

Answer 33

fusion of bcr-abl

Question 34

stage of carcinogen

Answer 34

initiation