Vecuronium (Norcuron®)

Question 1

Vecuronium - Class

Answer 1

Neuromuscular blocking agent (nondepolarizing)

Question 2

Vecuronium - Actions

Answer 2

• Skeletal muscle paralysis (including respiratory muscles)

* Prevents neuromuscular transmission by blocking the effect of acetylcholine at the neuromuscular junction

Question 3

Vecuronium - Indications

Answer 3

• RSI
• Skeletal muscle paralysis to facilitate endotracheal intubation
• RSI where Succinylcholine is contraindicated

Question 4

Vecuronium - Dosage/Route

Answer 4

• 0.1 mg/kg IVP initial dose

* May repeat as needed (long transports)

Question 5

Vecuronium - Side Effects

Answer 5

• Prolonged paralysis
• Bradycardia, hypotension & arrhythmias
• Excessive salivation

Question 6

Vecuronium - Contraindications

Answer 6

Pts with known hypersensitivity to the drug

Question 7

Vecuronium - Special Information

Answer 7

• Should not be administered unless persons skilled in endotracheal intubation are present
• ET equipment must be available & working
• O2 equipment, ventilatory management equipment, and emergency resuscitative equipment/drugs must be available
• Paralysis occurs within 2-3 min. and lasts for approximately 30-45 min
• Reconstitute with bacteriostatic water
• Has no effect on consciousness or pain threshold, adequate anesthesia should ALWAYS be used concurrently
• Can be used to maintain paralysis after intubation
• Use with caution in pts with renal or hepatic impairment/failure, pediatrics & elderly
• Can cause vagal stimulation resulting in bradycardia, hypotension & arrhythmias
• CANNOT be given IM

Question 8

Vecuronium - Pediatric Note

Answer 8

• Dosage 0.1mg/kg

* Do not use in infants < 7 wks