Ondansetron (Zofran®)

Question 0

Zofran - Actions

Answer 0

• Precise mode of action as anti-emetic is not clear
• Blocks the activation of serotonin 5-HT3 receptor sites located in vagal nerve terminals & the chemoreceptor trigger zone in the brain

Question 1

Zofran - Class

Answer 1

• Non-sedative anti-emetic

* Selective serotonin 5-HT3 receptor antagonist

Question 2

Zofran - Indications

Answer 2

Prevention & control of uncomplicated N/V

Question 3

Zofran - Dosage/Route

Answer 3

8 mg oral tablet, or 4 mg slow IVP (over 2 min) or IM

Question 4

Zofran - Side Effects

Answer 4

• Headache or dizziness
• Body aches, agitation, dysuria, HoTN, & rash
• Shivers

Question 5

Zofran - Contraindications

Answer 5

Known hypersensitivity to the drug

Question 6

Zofran - Special Information

Answer 6

• Use caution in pts with bowel obstruction

* May precipitate if mixed with alkaline solutions

Question 7

Zofran - Pediatric Note

Answer 7

• See Pediatric Drug Guide
• 4 mg oral tablet for ages 2-12 yrs
• 0.1 mg/kg slow IVP (over 2 min) or IM
• Max dose 4 mg