Vasoactive (Drugs)

Question 1

Nitric Oxide

Answer 1

Vasodilator - EDRF
(Endothelium-Derived Relaxing Factor)

Produced by Endothelial Cells

Question 2

Prostanoids

Answer 2

Vasodilator - (PGI2)

Produced by Endothelial Cells

Question 3

EDHF

Answer 3

Vasodilator -
(Endothelium-Derived Hyperpolarizing Factor)

Ca2+ activated K+ Channels
–> Causes vasodilator

Produced by Endothelial Cells

Question 4

CNP

Answer 4

Vasodilator - C-Natriuretic Peptide

Increases cGMP
–> Vasodilation

Produced by Endothelial Cells

Question 5

Endothelin

Answer 5

Vasoconstrictors

Produced by Endothelial Cells

Question 6

Thromboxane A2

Answer 6

Vasoconstrictors - Platlets

Produced by Endothelial Cells

Question 7

Angiotensin II

Answer 7

Vasoconstrictors
Produced by Endothelial Cells

MOA:
- Acts on Smooth Muscle Cells AT1 Receptors
–> Vasoconstriction

Question 8

Antidiuretic Hormone

Answer 8

Vasoconstriction - AKA Vasopressin

Produced by Posterior Pituitary
MOA:
- Acts on SMC V1 Receptor on Kidney
–> Causes water retention

Question 9

Bradykinin

Answer 9

Vasodilation

Produced by Kininogen
MOA:
- Endothelial NO generation
–> Vasodilation

Question 10

Kininogen

Answer 10

Is converted in Bradykinin by Kallikrein

Question 11

Kalikrein

Answer 11

Converts Kininogen into Bradykinin

Question 12

Renin

Answer 12

Converts Angiotensinogen into
Angiotensin I

Question 13

Angiotensin Converting Enzyme

Answer 13

Converts Angiotensin I to Angiotensin II

Inactivates Bradykinin vasodilator