Parkinson's Disease (Drugs)

Question 1

Levodopa

Answer 1

L-DOPA - Parkinson’s Treatment

MOA:
- Enters brain and is converted into Dopamine
–> Replaces deficient Dopamine

Question 2

Carbidopa

Answer 2

Parkinson’s Treatment
Given in combination Levodopa

MOA:
Prevents L-DOPA being converted into Dopamine in the periphery
–> Increase Dopamine

Question 3

Entacapone

Answer 3

Parkinson’s Treatment
Given in combination Levodopa

Prevents breakdown of Levodopa by inhibiting COMPT
–> Increase Dopamine

Question 4

Pramipexole

Answer 4

Dopamine Receptor Agonist

MOA:
- Activates DA Receptors responsible for motor control
–> Controls Symptoms of Parkinson’s DIsease

Question 5

Selegiline

Answer 5

MAO-B Inhibitor

MOA:
- Prevents Dopamine Degradation by inhibiting MAO-B

Question 6

Amantidine

Answer 6

Treats Parkinson’s Disease

MOA:
Increases Dopamine Release
Inhibits Amine Uptake
Acts on Dopamine Receptors

Question 7

Orphenadrine

Answer 7

Muscarinic Receptor Antagonist
- Treats Parkinson’s Disease in patients taking antipsychotics

Enhances Dopamine Release by inhibiting M4 mAchR that normally inhibit dopamine
–> Treats Parkinson’s Disease