Anxiolytic & Hypnotic (Drugs)

Question 1

Lorazepam

Answer 1

Benzodiazepine
- Treats Acute Anxiety

MOA:
Positive Allosteric GABA(A) Modulator
- Enhance opening of Cl-

Question 2

Flumazenil

Answer 2

Benzodiazepine Antagonist
- Reverse effects of Benzodiazepine upon overdose

MOA:
- Binds to GABA(A) and competes with Benzodiazepines

Question 3

Buspirone

Answer 3

5-HT(1A) Receptor Partial Agonist

MOA:
- Activates and desensitizes inhibitory 5-HT1A autoreceptors
–> Enhances 5-HT release

Question 4

SSRI

Answer 4

5-HT(1A) Receptor Partial Agonist
(Probably)

MOA:
- Increases 5-HT
–> Reduces depression

Question 5

Propranolol

Answer 5

Beta Blocker

Treats Somatic Symptoms of Anxiety
Reduces tachycardia, sweating, tremors

Question 6

Zolpidem

Answer 6

Hypnotic Drug - Benzodiazepine-like drug

Binds to GABA(A)
Specifically, alpha-1 subunit which is related to inducing sleep

Question 7

Zopiclone

Answer 7

Hypnotic Drug - Benzodiazepine-like drug

Binds to GABA(A)
Specifically, alpha-1 subunit which is related to inducing sleep

Question 8

Zaleplon

Answer 8

Hypnotic Drug - Benzodiazepine-like drug

Binds to GABA(A)
Specifically, alpha-1 subunit which is related to inducing sleep

Question 9

Diphenhydramine

Answer 9

Hypnotic Drug - First Generation Antihistamine (H1 Inverse Agonist)

Has CNS Depressive Effects causing sedation and anti-cholinergic effects (Blocks neural (M1) Muscarinic REceptors)

Question 10

Melatonin

Answer 10

Melatonin Receptor Agonist

Makes you sleepy